pidilizumab
mAbexperimental
Pidilizumab is a monoclonal antibody being developed by Medivation for the treatment of cancer and infectious diseases. Pidilizumab was originally thought to bind to the PD-1 immune checkpoint molecule, however, recent evidence suggests that Delta-like 1 (DLL1) is its primary binding target while binding to PD-1 is secondary and restricted to non-glycosylated and hypoglycosylated forms of this molecule. Pidilizumab causes in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells. — Wikipedia
Clinical trial activity
15 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
14
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2007 (NCT00532259)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 1
- Carcinoma, Hepatocellular · Phase 1/Phase 2
- Carcinoma, Renal Cell · Phase 2
- Colonic Neoplasms · Phase 1
- Colorectal Neoplasms · Phase 2
- Diffuse Intrinsic Pontine Glioma · Phase 1/Phase 2
- Hepatitis C, Chronic · Phase 1/Phase 2
- Lymphoma · Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Melanoma · Phase 2
- Multiple Myeloma · Phase 2
- Ovarian Neoplasms · Phase 1
- Pancreatic Neoplasms · Phase 2
- Prostatic Neoplasms · Phase 2
- Sarcoma · Phase 1
Mechanism of action
- Programmed cell death protein 1INHIBITOR
PDCD1 inhibitor
- Delta-like protein 1INHIBITOR
DLL1 inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPidilizumab ↗
- ChEMBLCHEMBL2108680 ↗
Also known as
- ct-011
- ct-011
- ct-011
- mdv9300
- pidilizumab
- pidilizumab
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02653989 | Phase 2 | Dec 1, 2016 | Medivation |
| NCT02530125 | Phase 2 | Sep 1, 2015 | Gateway for Cancer Research, National Cancer Institute (NCI), Northwestern University |
| NCT02077959 | Phase 1/Phase 2 (Phase 2) | Mar 3, 2014 | CureTech Ltd, Ohio State University |
| NCT01952769 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2014 | Hebrew University |
| NCT01420965 | Phase 2 | Sep 1, 2012 | Augusta University |
| NCT01313416 | Phase 2 | Sep 1, 2012 | Augusta University |
| NCT01435369 | Phase 2 | Nov 1, 2011 | Harvard University, Medivation |
| NCT01441765 | Phase 2 | Nov 1, 2011 | Harvard University, National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT01386502 | Phase 1 | Jun 15, 2011 | National Cancer Institute (NCI) |
| NCT01067287 | Phase 2 | Mar 1, 2010 | Department of Defense, Gateway for Cancer Research, Harvard University, Technion University |
| NCT00904722 | Phase 2 | Jan 1, 2010 | CureTech Ltd, University of Texas at Houston |
| NCT00966251 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2009 | CureTech Ltd, Hebrew University, Teva |
| NCT00962936 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2009 | CureTech Ltd, Hebrew University, Teva |
| NCT00890305 | Phase 2 | May 1, 2009 | Cornell University, Medivation |
| NCT00532259 | Phase 2 | Oct 1, 2007 | CureTech Ltd, Northwestern University, Tel Aviv University |
Showing 15 of 15 trials
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Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| CureTech Ltd | For profit | 5 | 3 | 1 | 2007 |
| Harvard University | Academic/Hospital | 3 | 2 | 1 | 2010 |
| Hebrew University | Academic/Hospital | 3 | 1 | 1 | 2009 |
| Medivation | For profit | 3 | 3 | 1 | 2009 |
| National Cancer Institute (NCI) | Government | 3 | 1 | 2 | 2011 |
| Augusta University | Academic/Hospital | 2 | 2 | 1 | 2012 |
| Gateway for Cancer Research | Academic/Hospital | 2 | 0 | 1 | 2010 |
| Northwestern University | Academic/Hospital | 2 | 1 | 1 | 2007 |
| Teva | For profit | 2 | 0 | 1 | 2009 |
| Cornell University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Department of Defense | Government | 1 | 0 | 1 | 2010 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2011 |
| Ohio State University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Technion University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Tel Aviv University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2010 |
16 organizations
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