lysozyme
Biologicalexperimental
Lysozyme is an antimicrobial enzyme produced by animals that forms part of the innate immune system. It is a glycoside hydrolase that catalyzes the following process:Hydrolysis of (1→4)-β-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins — Wikipedia
Clinical trial activity
6 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
3
Phase 4
2
Earliest trial started Aug 1, 2012 (NCT01645800)
Timeline
2010s
- Jan 1, 2016
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- PeptidoglycanDEGRADER
Peptidoglycan degrader
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLysozyme ↗
- ChEMBLCHEMBL2107935 ↗
Also known as
- lysozyme
- lysozyme
- lysozyme chloride
- lysozyme hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05519254 | Phase 3 | Jan 31, 2023 | National Institutes of Health (NIH), University of Washington |
| NCT05342272 | Phase 3 | Sep 22, 2017 | Spedali Civili di Brescia, University of Brescia |
| NCT03282045 | Phase 3 | Oct 31, 2016 | Istanbul University, Kocaeli University, MonitorCRO |
| NCT02925026 | N/A | Oct 1, 2016 | University of Malawi, Washington University in St. Louis |
| NCT01715493 | Phase 4 | Oct 1, 2012 | Eisai |
| NCT01645800 | Phase 4 | Aug 1, 2012 | Eisai |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Eisai | For profit | 2 | 2 | 1 | 2012 |
| Istanbul University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Kocaeli University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| MonitorCRO | For profit | 1 | 0 | 1 | 2016 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2023 |
| Spedali Civili di Brescia | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Brescia | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Malawi | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Washington University in St. Louis | Academic/Hospital | 1 | 1 | 1 | 2016 |
10 organizations
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