lurtotecan
Small moleculeexperimental
Lurtotecan is a semi-synthetic analog of camptothecin with antineoplastic activity. Liposomal lurtotecan was in clinical trials as a treatment for topotecan-resistant ovarian cancer, but was discontinued. — Wikipedia
Clinical trial activity
6 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 1999 (NCT00003891)
Timeline
Indications
Mechanism of action
- Topoisomerase IINHIBITOR
Topoisomerase I inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc3c(cc1c2CN1CCN(C)CC1)OCCO3- Mol. weight
- 518.57 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLurtotecan ↗
- ChEMBLCHEMBL305666 ↗
Also known as
- 7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(s)-camptothecin
- gg211
- gg-211
- gi147211
- gi 147211
- gi-147211
- gl147211c
- gl 147211c
- gl-147211c
- liposomal lurtotecan
- liposomal lurtotecan
- lurtotecan
- lurtotecan
- lurtotecan
- lurtotecan
- nx 211
- nx-211
- nx211 cpd
- osi211
- osi 211
- osi-211
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00046787 | Phase 2 | Sep 1, 2002 | Astellas, OSI Pharmaceuticals |
| NCT00046800 | Phase 2 | Sep 1, 2002 | Astellas, OSI Pharmaceuticals |
| NCT00022594 | Phase 2 | May 1, 2001 | Aix-University of Marseille, European Organisation for Research and Treatment of Cancer |
| NCT00010179 | Phase 2 | Jun 1, 2000 | Canadian Cancer Trials Group, Government of Canada |
| NCT00006036 | Phase 1 | Apr 1, 2000 | Canadian Cancer Trials Group, McMaster University |
| NCT00003891 | Phase 1 | Feb 1, 1999 | British Columbia Cancer Agency, Canadian Cancer Trials Group |
Showing 6 of 6 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Canadian Cancer Trials Group | Academic/Hospital | 3 | 3 | 2 | 1999 |
| Astellas | For profit | 2 | 2 | 1 | 2002 |
| OSI Pharmaceuticals | For profit | 2 | 0 | 1 | 2002 |
| Aix-University of Marseille | Academic/Hospital | 1 | 0 | 1 | 2001 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 1999 |
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 1 | 1 | 1 | 2001 |
| Government of Canada | Government | 1 | 0 | 1 | 2000 |
| McMaster University | Academic/Hospital | 1 | 0 | 1 | 2000 |
8 organizations
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