lb-100
Small moleculeexperimental
Clinical trial activity
7 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2013 (NCT01837667)
Timeline
2010s
- Jan 1, 2013
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
PPP2CA inhibitor
Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform inhibitor
Serine/threonine-protein phosphatase 5 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCN(C(=O)C2C(C(=O)O)[C@H]3CC[C@@H]2O3)CC1- Mol. weight
- 268.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297300 ↗
Also known as
- lb-100
- lb-100
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06012734 | Phase 1 | Dec 31, 2023 | Netherlands Cancer Institute |
| NCT06065462 | Phase 1/Phase 2 (Phase 2) | Nov 10, 2023 | University of Texas at Houston |
| NCT05809830 | Phase 1/Phase 2 (Phase 2) | May 29, 2023 | Grupo Espanol de Investigacion en Sarcomas, Universidad Autonoma de Madrid |
| NCT04560972 | Phase 1 | Nov 8, 2020 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT03886662 | Phase 1/Phase 2 (Phase 2) | Apr 30, 2019 | Lixte Biotechnology Holdings, Inc., University of South Florida |
| NCT03027388 | Early Phase 1 (Phase 1) | Jan 5, 2017 | National Cancer Institute (NCI) |
| NCT01837667 | Phase 1 | Feb 1, 2013 | Baylor University, City of Hope National Medical Center, Comprehensive Cancer Centers of Nevada, Lixte Biotechnology Holdings, Inc., Mayo Clinic |
Showing 7 of 7 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| City of Hope National Medical Center | Academic/Hospital | 2 | 1 | 1 | 2013 |
| Lixte Biotechnology Holdings, Inc. | For profit | 2 | 2 | 2 | 2013 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 1 | 2017 |
| Baylor University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Comprehensive Cancer Centers of Nevada | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Grupo Espanol de Investigacion en Sarcomas | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Netherlands Cancer Institute | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Universidad Autonoma de Madrid | Academic/Hospital | 1 | 0 | 1 | 2023 |
| University of South Florida | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2023 |
11 organizations
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