lanabecestat
Small moleculeexperimental
Lanabecestat is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. A BACE inhibitor in theory would prevent the buildup of beta-amyloid and may help slow or stop the progression of Alzheimer's disease. — Wikipedia
Clinical trial activity
12 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
9
Phase 2
2
Phase 3
3
Phase 4
0
Earliest trial started Sep 1, 2014 (NCT02245737)
Timeline
Indications
Mechanism of action
- Beta-secretase 1INHIBITOR
BACE1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1- Mol. weight
- 412.54 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLanabecestat ↗
- ChEMBLCHEMBL3989948 ↗
Also known as
- lanabecestat
- lanabecestat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03545087 | Phase 1 | Jun 30, 2018 | AstraZeneca, Eli Lilly |
| NCT03506399 | Phase 1 | Jun 30, 2018 | AstraZeneca, Eli Lilly |
| NCT03499041 | Phase 1 | Jun 30, 2018 | AstraZeneca, Eli Lilly |
| NCT03222427 | Phase 1 | Jan 15, 2018 | AstraZeneca, Eli Lilly |
| NCT02972658 | Phase 3 | Mar 15, 2017 | AstraZeneca, Eli Lilly |
| NCT03019549 | Phase 1 | Jan 12, 2017 | AstraZeneca, Eli Lilly |
| NCT02783573 | Phase 3 | Jul 1, 2016 | AstraZeneca, Eli Lilly |
| NCT02663128 | Phase 1 | Jan 1, 2016 | AstraZeneca, Eli Lilly |
| NCT02568397 | Phase 1 | Oct 1, 2015 | AstraZeneca, Eli Lilly |
| NCT02540668 | Phase 1 | Sep 1, 2015 | AstraZeneca, Eli Lilly |
| NCT02406261 | Phase 1 | Apr 1, 2015 | AstraZeneca, Eli Lilly |
| NCT02245737 | Phase 2/Phase 3 (Phase 3) | Sep 1, 2014 | AstraZeneca, Eli Lilly |
Showing 12 of 12 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AstraZeneca | For profit | 12 | 0 | 2 | 2014 |
| Eli Lilly | For profit | 12 | 12 | 2 | 2014 |
2 organizations
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