theanine
L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis (alongside green tea catechins and caffeine) and is known to promote relaxation without sedation. It appears to be effective at this as well as reducing stress at standard dosages. L-theanine was discovered as a constituent of green tea in 1949 and was approved in Japan in 1964 for unlimited use in all foods, including chocolates, soft drinks, and herb teas, except infant foods. It also provides a unique umami (brothy or savory) taste and flavor to green tea infusion. L-theanine may help relieve stress by inducing a relaxing effect without drowsiness and may also possess immunologic attributes. Theanine may also have effects on the cardiovascular system and play a preventative role in cancer; however, limited clinical information is available to support these claims. L-Theanine and its positive effects on cognitive performance is one of its most important functions. Because of chemical structure of L-Theanine similar to glutamate it can act as a neurotransmitter related to memory. In a study made on rats, it was found out that L-Theanine modulated the serotonin and dopamine levels and increased learning skills with memory. In addition, it is stated that L-Theanine increases neuro - throphine mRNA level by activating its neuro - transmitter inhibiting system and supports the central nervous system that helps the development of brain functions. L-Theanine had a positive effect on memory and had positive effects on the treatment and prevention of Alzheimer. Theanine is an antagonist of the NMDA receptors (albeit with fairly weak efficacy) and can inhibit synaptic release of glutamate via blocking the transporter competitively. Theanine may also reduce glutamate levels, but this is also a fairly weak mechanism requiring a high concentration of theanine. — NCATS
Clinical trial activity
21 trials · 24 clinical orgs · 0 marketing orgs
Earliest trial started Oct 1, 2005 (NCT00291070)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- tryptophanUnclear
tryptophan unclear
Chemistry & pharmacology
SMILES
CCNC(=O)CC[C@H](N)C(O)=O- Mol. weight
- 174.1977 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTheanine ↗
- NCATS8021PR16QO ↗
- ChEMBLCHEMBL3039113 ↗
Also known as
- delta-glutamylethylamide
- gamma-glutamylethylamide
- l-glutamic acid-gamma-ethylamide
- l-theanine
- l-theanine
- l-theanine
- n-ethyl-l-glutamine
- n-ethyl-l-glutamine
- theanine
- theanine
- theanine
- theanine, (d)-isomer
- theanine, (dl)-isomer
- theanine, (l)-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07220447 | Early Phase 1 (Phase 1) | Dec 21, 2025 | City of Hope National Medical Center, National Cancer Institute (NCI) |
| NCT07004023 | N/A | Oct 31, 2025 | Ethical Naturals, Inc., KGK Science Inc. |
| NCT07268573 | N/A | Aug 1, 2025 | Sinop University |
| NCT06889584 | N/A | Feb 15, 2025 | University of South Carolina |
| NCT06621797 | N/A | May 1, 2023 | Hacettepe University |
| NCT05808595 | Phase 2 | Apr 11, 2023 | Ethical Naturals, Inc., KGK Science Inc. |
| NCT05854017 | N/A | Feb 9, 2023 | Supplement Formulators, Inc. |
| NCT05450952 | N/A | Apr 21, 2022 | Supplement Formulators, Inc. |
| NCT05032729 | N/A | Nov 6, 2021 | CQUniversity Australia, PepsiCo |
| NCT04749745 | Early Phase 1 (Phase 1) | Jun 9, 2020 | Brown University |
| NCT04706494 | Phase 1 | Feb 2, 2020 | Ethical Naturals, Inc., KGK Science Inc. |
| NCT04056650 | Phase 4 | Sep 2, 2019 | Icahn School of Medicine at Mount Sinai |
| NCT03965819 | N/A | May 31, 2019 | KGK Science Inc., LifeSeasons Inc. |
| NCT03533556 | Early Phase 1 (Phase 1) | May 14, 2018 | Texas Tech University |
| NCT02298530 | N/A | Mar 31, 2015 | Unilever, University of London |
| NCT01851122 | N/A | Nov 1, 2011 | University of Texas at Houston |
| NCT01361204 | N/A | May 1, 2011 | University of Shizuoka |
| NCT01831986 | N/A | Jan 1, 2011 | Sha'ar Menashe Mental Health Center, Technion University |
| NCT00981955 | Phase 4 | Aug 1, 2009 | Northumbria University |
| NCT00372151 | Phase 3 | Oct 1, 2006 | Ben Gurion University, Sha'ar Menashe Mental Health Center, Stanley Medical Research Institute |
Organizations
Research & Development (24)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| KGK Science Inc. | For profit | 4 | 0 | 3 | 2019 |
| Ethical Naturals, Inc. | For profit | 3 | 3 | 3 | 2020 |
| Sha'ar Menashe Mental Health Center | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Supplement Formulators, Inc. | For profit | 2 | 2 | 1 | 2022 |
| Ben Gurion University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Brown University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| City of Hope National Medical Center | Academic/Hospital | 1 | 1 | 1 | 2025 |
| CQUniversity Australia | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Hacettepe University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2019 |
| LifeSeasons Inc. | For profit | 1 | 1 | 1 | 2019 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2025 |
| Northumbria University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| PepsiCo | For profit | 1 | 1 | 1 | 2021 |
| Sinop University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Stanley Medical Research Institute | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Technion University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Texas Tech University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Unilever | For profit | 1 | 1 | 1 | 2015 |
| University of British Columbia | Academic/Hospital | 1 | 1 | 1 | 2005 |