kh176
Small moleculeexperimental
Clinical trial activity
7 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
6
Phase 3
1
Phase 4
0
Earliest trial started May 1, 2015 (NCT02544217)
Timeline
Indications
Studied for
Mechanism of action
- Unspecified targetOTHER
ROS-redox modulator
In addition, an active metabolite inhibits prostaglandin E synthase.
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
Cc1c(C)c2c(c(C)c1O)CC[C@@](C)(C(=O)N[C@@H]1CCCNC1)O2- Mol. weight
- 332.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4802153 ↗
Also known as
- kh176
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07298005 | Phase 2 | Feb 28, 2026 | Khondrion BV, University of Amsterdam, ZonMw: The Netherlands Organisation for Health Research and Development |
| NCT06451757 | Phase 3 | Jan 2, 2025 | Khondrion BV |
| NCT04604548 | Phase 2 | Aug 9, 2021 | Certara, Julius Clinical, The Netherlands, Khondrion BV, ProPharma |
| NCT04846036 | Phase 2 | Feb 1, 2021 | Ardena, Certara, European Regional Development Fund, Julius Clinical, The Netherlands, Khondrion BV, ProPharma, Radboud University |
| NCT04165239 | Phase 2 | Oct 30, 2019 | Julius Clinical, The Netherlands, Khondrion BV |
| NCT02909400 | Phase 2 | Sep 1, 2016 | Khondrion BV, Radboud University |
| NCT02544217 | Phase 1 | May 1, 2015 | Ghent University, Khondrion BV |
Showing 7 of 7 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Khondrion BV | For profit | 7 | 6 | 3 | 2015 |
| Julius Clinical, The Netherlands | For profit | 3 | 0 | 1 | 2019 |
| Certara | For profit | 2 | 0 | 1 | 2021 |
| ProPharma | For profit | 2 | 0 | 1 | 2021 |
| Radboud University | Academic/Hospital | 2 | 0 | 1 | 2016 |
| Ardena | For profit | 1 | 0 | 1 | 2021 |
| European Regional Development Fund | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Ghent University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of Amsterdam | Academic/Hospital | 1 | 1 | 1 | 2026 |
| ZonMw: The Netherlands Organisation for Health Research and Development | Academic/Hospital | 1 | 0 | 1 | 2026 |
10 organizations
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