kallikrein
Biologicalexperimental
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation. — Wikipedia
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
0
Phase 3
0
Phase 4
3
Earliest trial started Aug 1, 2015 (NCT02562183)
Timeline
2020s
- Jan 1, 2021
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaKallikrein ↗
Also known as
- kallikrein
- kallikrein
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06380699 | Phase 1 | Mar 16, 2023 | Government of China, Nanjing University |
| NCT06388772 | Phase 1 | Jul 5, 2021 | Government of China, Nanjing University |
| NCT04102956 | Phase 4 | Jul 1, 2017 | Hebei University |
| NCT04325932 | Phase 4 | Jan 31, 2016 | Zhejiang University |
| NCT02562183 | Phase 4 | Aug 1, 2015 | Techpool Bio-Pharma Co., Ltd., Tsinghua University |
Showing 5 of 5 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Government of China | Government | 2 | 2 | 1 | 2021 |
| Nanjing University | Academic/Hospital | 2 | 0 | 1 | 2021 |
| Hebei University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Techpool Bio-Pharma Co., Ltd. | For profit | 1 | 1 | 1 | 2015 |
| Tsinghua University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2016 |
6 organizations
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