modimelanotide
Modimelanotide (INN; development code AP-214, ABT-719, and ZP-1480) is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development by, at different times, Action Pharma, Abbott Laboratories, AbbVie, and Zealand for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist, with IC50 values of 2.9 nM, 1.9 nM, 3.7 nM, and 110 nM at the MC1, MC3, MC4, and MC5 receptors. Modimelanotide failed clinical trials for acute kidney injury despite showing efficacy in animal models, and development was not further pursued. — Wikipedia
Clinical trial activity
5 trials · 4 clinical orgs · 0 marketing orgs
Earliest trial started Mar 1, 2008 (NCT00628264)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- Melanocortin receptor 1AGONIST
MC1R agonist
- Melanocortin receptor 3AGONIST
MC3R agonist
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaModimelanotide ↗
- ChEMBLCHEMBL3545104 ↗
Also known as
- a 816719.1
- a-816719.1
- abt719
- abt 719
- abt-719
- abt-719
- abt-719
- abt-719
- ap214
- ap214
- ap 214
- ap-214
- ap-214
- ap-214
- ap214 peptide
- modimelanotide
- zp-1480
- zp-1480
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01897519 | Phase 2 | May 1, 2013 | AbbVie |
| NCT01777165 | Phase 2 | Feb 1, 2013 | AbbVie |
| NCT01256372 | Phase 2 | Oct 1, 2010 | Action Pharma A/S |
| NCT00903604 | Phase 2 | May 1, 2009 | Action Pharma A/S, University of Copenhagen |
| NCT00628264 | Phase 2 | Mar 1, 2008 | Action Pharma A/S, University of Florida |
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Action Pharma A/S | For profit | 3 | 3 | 1 | 2008 |
| AbbVie | For profit | 2 | 2 | 1 | 2013 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 2009 |
| University of Florida | Academic/Hospital | 1 | 0 | 1 | 2008 |