cobalamin
Small moleculeexperimental
Cobalamin (vitamin B12) is a cobalt-containing, B complex vitamin. B12 group (cobalamins) consist of cyanocobalamin, hydroxocobalamin, methylcobalamin and cobalamid. Neither plants nor animals are independently capable of constructing vitamin B12. Only bacteria and archaea have the enzymes required for its biosynthesis. Therefore, humans must absorb it from food. Excellent sources of B12 are foods of ruminant origin, so dairy and meat products play an important role in efforts to meet the official daily B12 intake. Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system. Vitamin B12 is used to treat vitamin B12 deficiency, including pernicious anemia. — NCATS
Clinical trial activity
63 trials · 103 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
13
Phase 3
13
Phase 4
7
Earliest trial started Oct 1, 2004 (NCT04731948)
Timeline
Indications
Approved for
Studied for
- Amyotrophic Lateral Sclerosis · Phase 1
- Anemia · Phase 4
- Antioxidants · Phase 4
- Brain Injuries, Traumatic · Phase 3
- Carcinoma, Non-Small-Cell Lung · Phase 2/Phase 3
- Carcinoma, Transitional Cell · Phase 3
- Carpal Tunnel Syndrome · Phase 1
- Coronavirus Infections · Phase 3
- COVID-19 · Phase 3
- Dementia · Phase 1
- Diabetes Mellitus · Phase 4
- Drug-Related Side Effects and Adverse Reactions · Phase 2/Phase 3
- Infertility, Male · Phase 4
- Ischemic Stroke · Phase 2/Phase 3
- Kidney Failure, Chronic · Phase 3
- Lung Neoplasms · Phase 2/Phase 3
- Lymphoma, Large-Cell, Immunoblastic · Phase 2/Phase 3
- Lymphoma, T-Cell · Phase 3
- Malnutrition · Early Phase 1
- Neoplasm Metastasis · Phase 1/Phase 2
- Neoplasms · Phase 4
- Obesity · Phase 4
- Oxidative Stress · Phase 2/Phase 3
- Pharmacology · Phase 2/Phase 3
- Pregnancy Complications · Phase 4
- Premature Ejaculation · Phase 3
- Psychotic Disorders · Phase 3
- Schizophrenia · Phase 4
- Semen Analysis · Phase 4
- Stomach Neoplasms · Early Phase 1
- Stomatitis · Phase 2
- Stress Disorders, Post-Traumatic · Phase 1
- Stroke · Phase 1
- Ureteral Neoplasms · Phase 3
- Urinary Bladder Neoplasms · Phase 3
- Uterine Cervical Neoplasms · Phase 2
- Vitamin B 12 Deficiency · Phase 4
Mechanism of action
- Unspecified targetOTHER
Supplement
- Unspecified targetSupplementation
supplementation
Chemistry & pharmacology
Loading structure…
SMILES
[Co++].C[C@@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2[N-]C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@@H]6[C@@H](CO)O[C@@H]([C@@H]6O)N7C=NC8=C7C=C(C)C(C)=C8- Mol. weight
- 1329.3478 g/mol
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMenet ↗
- NCATS8406EY2OQA ↗
- ChEMBLCHEMBL4297272 ↗
- WikipediaVitamin B12 ↗
- WikipediaB12 ↗
Also known as
- b12
- b12
- cobalamin
- cobalamin
- cobalamin
- cobalamine
- cobalamin(iii)
- menet
- menet
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06983223 | N/A | Aug 15, 2025 | Liaquat University of Medical & Health Sciences |
| NCT07048860 | N/A | Jul 9, 2025 | University of Toulouse |
| NCT07029698 | Phase 4 | Apr 16, 2025 | Medice Arzneimittel Pütter GmbH & Co KG |
| NCT06749756 | N/A | Dec 15, 2024 | University of Electronic Science and Technology of China |
| NCT06632470 | Phase 1 | Oct 15, 2024 | Baermed, Tarumanagara University |
| NCT06661083 | N/A | Aug 1, 2024 | AGUNCO Obstetrics and Gynecology Centre |
| NCT06639789 | N/A | Jul 1, 2024 | Catholic University of Murcia, Universidad Católica San Antonio de Murcia |
| NCT06376591 | N/A | Apr 12, 2024 | Liaquat University of Medical & Health Sciences |
| NCT06772220 | N/A | Mar 5, 2024 | Oregon Health and Science University |
| NCT07304453 | Phase 2 | Jan 7, 2024 | Karbala University, Kufa University |
| NCT06098456 | Phase 2 | Nov 1, 2023 | Centro di Ricerca Clinica Salentino |
| NCT06100146 | N/A | Sep 6, 2023 | Addis Ababa University, Arba Minch University, Ethiopia, Ghent University, Institut et Haute école de la Santé, La Source |
| NCT05796401 | Phase 3 | Jun 15, 2023 | Centre Hospitalier St Anne |
| NCT05426395 | Phase 1 | Dec 31, 2022 | George Washington University, Ifakara Health Institute |
| NCT05638633 | Phase 3 | Nov 11, 2022 | Julius-Maximilians University, Universitaetsklinikum Schleswig-Holstein, University of Tuebingen |
| NCT05931965 | N/A | Oct 5, 2022 | Riphah International University |
| NCT06241638 | N/A | Jul 1, 2022 | Al-Balqa Applied University |
| NCT05625308 | N/A | Jul 1, 2022 | Lo.Li. Pharma, Ltd. |
| NCT05385042 | Phase 4 | Jun 18, 2022 | University of Oxford |
| NCT05096663 | Phase 2/Phase 3 (Phase 3) | Apr 28, 2022 | National Cancer Institute (NCI), Southwest Oncology Group |
Showing 20 of 63 trials
Page 1 / 4
Organizations
Research & Development (103)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Jinlin University | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Liaquat University of Medical & Health Sciences | Academic/Hospital | 2 | 2 | 1 | 2024 |
| University of Bergen | Academic/Hospital | 2 | 1 | 2 | 2004 |
| Addis Ababa University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| AGUNCO Obstetrics and Gynecology Centre | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Al-Balqa Applied University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Arba Minch University, Ethiopia | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Arogyavaram Medical Centre | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Baermed | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Band of Hope Foundation | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Bangladesh Medical University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Catholic Health Initiatives | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Catholic University of Murcia | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Centre Hospitalier St Anne | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Centro di Ricerca Clinica Salentino | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Cinnagen | For profit | 1 | 1 | 1 | 2016 |
| Columbia University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2017 |
103 organizations
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