indibulin
Small moleculeexperimental
Clinical trial activity
6 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2003 (NCT00591136)
Timeline
2000s
- Jan 1, 2003
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- TubulinINHIBITOR
Tubulin inhibitor
Destabilizes microtubules and blocks cell cycle transition specifically at G2-M phase.
Binding site of D-24851 does not overlap with tubulin binding sites of vincristine or colchicine.
- Tubulin beta-4B chain (TUBB4B) ↗
- Tubulin beta-1 chain (TUBB1) ↗
- Tubulin alpha-3C chain (TUBA3C) ↗
- Tubulin alpha-4A chain (TUBA4A) ↗
- Tubulin beta-3 chain (TUBB3) ↗
- Tubulin alpha-1A chain (TUBA1A) ↗
- Tubulin beta-4A chain (TUBB4A) ↗
- Tubulin beta-8 chain (TUBB8) ↗
- Tubulin beta chain (TUBB) ↗
- Tubulin alpha-1B chain (TUBA1B) ↗
- Tubulin alpha-1C chain (TUBA1C) ↗
- Tubulin alpha-3E chain (TUBA3E) ↗
- Tubulin beta-2A chain (TUBB2A) ↗
- Tubulin beta-2B chain (TUBB2B) ↗
- Tubulin beta-6 chain (TUBB6) ↗
Chemistry & pharmacology
Loading structure…
SMILES
O=C(Nc1ccncc1)C(=O)c1cn(Cc2ccc(Cl)cc2)c2ccccc12- Mol. weight
- 389.84 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL49642 ↗
Also known as
- d 24851
- d-24851
- d-24851
- d-24851
- indibulin
- indibulin
- indibulin
- indibulin
- n-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide
- n-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide
- zio-301
- zio-301
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01113970 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2010 | Cornell University, Ziopharm |
| NCT00726687 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2008 | Ziopharm |
| NCT00591383 | Phase 1 | Jan 1, 2008 | Ziopharm |
| NCT00591890 | Phase 1 | Oct 1, 2007 | Ziopharm |
| NCT00591292 | Phase 1 | Jun 1, 2007 | Ziopharm |
| NCT00591136 | Phase 1 | Apr 1, 2003 | Ziopharm |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ziopharm | For profit | 6 | 6 | 2 | 2003 |
| Cornell University | Academic/Hospital | 1 | 0 | 1 | 2010 |
2 organizations
Page 1 / 1