img-7289
Small moleculeexperimental
Clinical trial activity
14 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
9
Phase 3
2
Phase 4
0
Earliest trial started Oct 1, 2016 (NCT02842827)
Timeline
Indications
Mechanism of action
- LSD1/CoREST complexINHIBITOR
LSD1/CoREST complex inhibitor
Lysine-specific histone demethylase 1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCN(CC1)C(=O)[C@H](CCCN[C@@H]2C[C@H]2C3=CC=C(F)C=C3)NC(=O)C4=CC=C(C=C4)N5C=CN=N5- Mol. weight
- 519.6137 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSY2T4ALDEAT ↗
- ChEMBLCHEMBL4297289 ↗
Also known as
- img-7289
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07049939 | Phase 1 | Aug 20, 2025 | Merck |
| NCT06596668 | Phase 1 | Oct 2, 2024 | Merck |
| NCT06456346 | Phase 3 | Jul 16, 2024 | Merck |
| NCT06351631 | Phase 3 | May 23, 2024 | Merck |
| NCT05558696 | Phase 2 | Dec 31, 2022 | Imago BioSciences |
| NCT05597306 | Phase 1 | Nov 19, 2022 | Imago BioSciences, University of Miami |
| NCT05569538 | Phase 2 | Nov 1, 2022 | Imago BioSciences, The University of Hong Kong |
| NCT05191797 | Phase 1/Phase 2 (Phase 2) | Apr 11, 2022 | Imago BioSciences, National Cancer Institute (NCI), University of Washington |
| NCT05223920 | Phase 2 | Dec 16, 2021 | Imago BioSciences |
| NCT04262141 | Phase 2 | May 31, 2020 | Imago BioSciences, University of Miami |
| NCT04254978 | Phase 2 | Apr 30, 2020 | Imago BioSciences |
| NCT04081220 | Phase 2 | Oct 31, 2019 | Imago BioSciences, University of Texas, San Antonio |
| NCT03136185 | Phase 1 | May 1, 2017 | Imago BioSciences, University of Adelaide |
| NCT02842827 | Phase 1 | Oct 1, 2016 | Imago BioSciences, University of Adelaide |
Showing 14 of 14 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Imago BioSciences | For profit | 10 | 5 | 2 | 2016 |
| Merck | For profit | 4 | 4 | 2 | 2024 |
| University of Adelaide | Academic/Hospital | 2 | 0 | 1 | 2016 |
| University of Miami | Academic/Hospital | 2 | 2 | 2 | 2020 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2022 |
| The University of Hong Kong | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Texas, San Antonio | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2022 |
8 organizations
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