homatropine

Small moleculeapproved

Approved

Mar 23, 1943

Homatropine (used in a form of bromide or methylbromide salts) is an analogue of atropine, which acts as an antagonist of muscarinic receptors. Homatropine was approved for the treatment of cough in combination with hydrocodone bitartrate. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 18 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Oct 1, 2013 (NCT02344732)

Timeline

1880s

Jul 1, 1881
Evidence of US Marketing

1940s

Mar 23, 1943
Genus Oncology, LLC — Earliest FDA Approval
Mar 23, 1943
Genus Oncology, LLC — Marketing Organization
Mar 23, 1943
Genus Oncology, LLC — NDA Secondary Org
Mar 23, 1943
Genus Oncology, LLC — NDA Organization

1970s

Apr 11, 1979
Mission Pharmacal — Marketing Organization

1980s

Mar 3, 1983
Wockhardt — Marketing Organization
Jul 30, 1985
King Pharmaceuticals — Marketing Organization

1990s

Jul 19, 1999
Teva — Marketing Organization

2000s

Dec 1, 2000
Actavis — Marketing Organization
Feb 8, 2008
Akorn, Inc. — Marketing Organization
Feb 8, 2008
Hi Tech Pharmaceuticals — Marketing Organization

2010s

Apr 20, 2011
Novel Anti-Infective Technologies, LLC — Marketing Organization
Jan 1, 2014
Earliest Phase 3 Sponsor(trial)
Feb 15, 2017
Padagis Us — Marketing Organization
Feb 15, 2017
Paddock Laboratories — Marketing Organization
Feb 21, 2017
Abhai LLC — Marketing Organization
Mar 6, 2017
Sciegen Pharmaceticals — Marketing Organization
Mar 6, 2017
Torrent Pharmaceuticals Limited — Marketing Organization
Aug 7, 2017
Avanthi Pharma — Marketing Organization
Jun 11, 2019
Nostrum Laboratories — Marketing Organization
Jun 11, 2019
Esteve Labs — Marketing Organization

Indications

Approved for

Studied for

Headache · Phase 3

Mechanism of action

Unspecified targetOTHER
Unknown
Antitussive drug; probable action in the CNS cough centre

Combination products

hycodan
with hydrocodone
Also known as tussigon

Approval history

approvedMar 23, 1943
approvedJul 1, 1881

Chemistry & pharmacology

Loading structure…

SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3

Mol. weight: 275.3428 g/mol
Lipinski Ro5: Pass
Rule of 3: Yes
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropanium bromide mandelate
3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropanium bromide mandelate
8-methylhomatropinium bromide
8-methylhomatropinium bromide
ak-homatropine
americal brand of homatropine hydrobromide
dl-homatropine hydrobromide
dl-homatropine hydrobromide
equipin
equipin
hmbromide
homapin
homapin
homapin-10
homapin-10
homapin-5
homapin-5
homatropin
homatropine
homatropine
homatropine
homatropine
homatropine
homatropine
homatropine
homatropine
(+/-)-homatropine
homatropine, (3(s)-endo)-isomer
homatropine, exo-(+-)-isomer
homatropine hydrobromide
homatropine hydrobromide
homatropine hydrobromide
homatropine hydrobromide, (endo-(+-)-isomer)
homatropine hydrochloride, (endo-(+-)-isomer)
homatropine merck
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide
homatropine methylbromide, (3(r)-endo)-isomer
homatropine methylbromide, (3(s)-endo)-isomer
homatropine methylbromide, endo-(+-)-isomer
homatropine methylbromide iodide, (3(r)-endo)-isomer
homatropine methylbromide iodide, (3(s)-endo)-isomer
homatropine sulfate
homatropine sulfate
homatropine sulfate
homatropine sulfate
homatropine sulfate (1:1), (3(r)-endo)-isomer
homatropine sulfate (1:1), (3(s)-endo)-isomer
homatropine sulfate (2:1), endo-isomer
homatropini methylbromidum
homatropini methylbromidum
homatropin - pos
homoatropine
i - homatrine
isopto homatropine
isopto homatropine
isopto homatropine
mandelyltropeine
(+/-)-mandelyltropine
methatropine
methylbromure d'homatropine
methylbromure d'homatropine
methylhomatropine
methylhomatropine
methylhomatropine
methylhomatropine
methylhomatropine
methylhomatropine bromide
methylhomatropine bromide
methylhomatropine bromide
methylhomatropinum bromatum
methylhomatropinum bromatum
methyloctatropine bromide
metilbromuro de homatropina
metilbromuro de homatropina
minims-homatropin
minims-homatropine hydrobromide
omatropina metilbromuro
omatropina metilbromuro
tropine mandelate
tropinium methobromide mandelate
tropinium methobromide mandelate

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT01408069	Phase 3	Mar 1, 2014	EMS S/A
NCT02344732	N/A	Oct 1, 2013	University of Science Malaysia

Showing 2 of 2 trials

Page 1 / 1

Organizations

Research & Development (2)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
EMS S/A	For profit	1	1	1	2014
University of Science Malaysia	Academic/Hospital	1	1	1	2013

2 organizations

Page 1 / 1

Marketing (23)

Organization	Org type	Relationship	Date
Abhai LLC	For profit	MKTG	Feb 21, 2017
Actavis	For profit	MKTG	Dec 1, 2000
Actavis	For profit	SYN	Jul 5, 1983
Akorn, Inc.	For profit	MKTG	Feb 8, 2008
Avanthi Pharma	For profit	MKTG	Aug 7, 2017
Esteve Labs	For profit	SYN	Jun 11, 2019
Esteve Labs	For profit	MKTG	Jun 11, 2019
Genus Oncology, LLC	For profit	MKTG	Mar 23, 1943
Genus Oncology, LLC	For profit	NDA2	Mar 23, 1943
Genus Oncology, LLC	For profit	NDA	Mar 23, 1943
Halsey	For profit	MKTG	—
Hi Tech Pharmaceuticals	For profit	MKTG	Feb 8, 2008
King Pharmaceuticals	For profit	MKTG	Jul 30, 1985
Mission Pharmacal	For profit	MKTG	Apr 11, 1979
Nostrum Laboratories	For profit	MKTG	Jun 11, 2019
Novel Anti-Infective Technologies, LLC	For profit	MKTG	Apr 20, 2011
Padagis Us	For profit	MKTG	Feb 15, 2017
Paddock Laboratories	For profit	SYN	Feb 15, 2017
Paddock Laboratories	For profit	MKTG	Feb 15, 2017
Sciegen Pharmaceticals	For profit	MKTG	Mar 6, 2017
Teva	For profit	MKTG	Jul 19, 1999
Torrent Pharmaceuticals Limited	For profit	MKTG	Mar 6, 2017
Wockhardt	For profit	MKTG	Mar 3, 1983