dorzagliatin
Small moleculeexperimental
Clinical trial activity
22 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
13
Phase 2
7
Phase 3
3
Phase 4
1
Earliest trial started Sep 1, 2013 (NCT01952535)
Timeline
Indications
Approved for
Mechanism of action
- Hexokinase type IVACTIVATOR
GCK activator
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)C[C@@H](C(=O)Nc1ccn(C[C@@H](O)CO)n1)N1CC(Oc2ccccc2Cl)=CC1=O- Mol. weight
- 462.93 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297508 ↗
Also known as
- hms5552
- hms5552
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06995651 | Phase 1 | Dec 31, 2025 | University of Pennsylvania |
| NCT06976658 | Phase 2 | May 28, 2025 | Chinese University of Hong Kong |
| NCT06671340 | N/A | Nov 15, 2024 | Chinese University of Hong Kong |
| NCT06222476 | N/A | Feb 20, 2024 | Nanjing University |
| NCT06263348 | Phase 4 | Dec 20, 2023 | Hua Medicine Limited |
| NCT05468229 | Phase 1/Phase 2 (Phase 2) | Aug 31, 2022 | Chinese University of Hong Kong |
| NCT05098470 | Phase 3 | Jan 31, 2022 | University of Virginia |
| NCT04531631 | Phase 2 | Sep 30, 2020 | Chinese University of Hong Kong |
| NCT04324424 | Phase 1 | Apr 23, 2019 | Hua Medicine Limited, Sichuan University |
| NCT04426708 | Phase 1 | Feb 18, 2019 | Hua Medicine Limited |
| NCT03790839 | Phase 1 | Jan 31, 2019 | Frontage Laboratories, Inc., Hua Medicine Limited |
| NCT03790787 | Phase 1 | Jan 31, 2019 | Hua Medicine Limited |
| NCT04080609 | Phase 1 | Mar 27, 2018 | Hua Medicine Limited |
| NCT04080596 | Phase 1 | Oct 13, 2017 | Hua Medicine Limited |
| NCT03173391 | Phase 3 | Aug 31, 2017 | Hua Medicine Limited, Tigermed Consulting Co., Ltd |
| NCT03141073 | Phase 3 | Aug 1, 2017 | Covance, Hua Medicine Limited, Peking University |
| NCT03158506 | Phase 1 | Mar 29, 2017 | Hua Medicine Limited |
| NCT02597400 | Phase 1 | Oct 1, 2015 | Frontage Laboratories, Inc., Hua Medicine Limited |
| NCT02561338 | Phase 2 | Sep 1, 2015 | Hua Medicine Limited, Nanjing University, Tigermed Consulting Co., Ltd |
| NCT02386982 | Phase 1 | Mar 1, 2015 | Hua Medicine Limited |
Showing 20 of 22 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Hua Medicine Limited | For profit | 15 | 15 | 4 | 2013 |
| Chinese University of Hong Kong | Academic/Hospital | 4 | 4 | 2 | 2020 |
| Frontage Laboratories, Inc. | For profit | 2 | 0 | 1 | 2015 |
| Nanjing University | Academic/Hospital | 2 | 1 | 2 | 2015 |
| Tigermed Consulting Co., Ltd | For profit | 2 | 0 | 2 | 2015 |
| Covance | For profit | 1 | 0 | 1 | 2017 |
| Fudan University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Nanjing Medical University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Peking University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Sichuan University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Pennsylvania | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Virginia | Academic/Hospital | 1 | 1 | 1 | 2022 |
12 organizations
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