hydroxymethylbutyrate

Small moleculeexperimental

β-Hydroxy β-methylbutyric acid (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS. In healthy adults, supplementation with HMB has been shown to increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce skeletal muscle damage from exercise, improve aerobic exercise performance, and expedite recovery from exercise. Medical reviews and meta-analyses indicate that HMB supplementation also helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss. HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue. No adverse effects from long-term use as a dietary supplement in adults have been found. — Wikipedia

Clinical trial activity

20 trials · 26 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
0
Phase 3
2
Phase 4
2

Earliest trial started Jun 1, 2013 (NCT01850251)

Timeline

2010s

  1. Jan 1, 2014

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2019

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Mechanism of action

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • calcium beta-hydroxy-beta-methylbutyrate
  • calcium beta-hydroxy-beta-methylbutyrate
  • hydroxymethylbutyrate
  • hydroxymethylbutyrate

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07142941N/ASep 1, 2025Sun Yat-Sen University
NCT07171593N/AMar 4, 2024Sun Yat-Sen University
NCT05877846N/ANov 1, 2023University of North Carolina at Chapel Hill
NCT05400733N/AJun 15, 2022Texas A&M University
NCT05384951N/AMay 15, 2022Gillette Children's Specialty Healthcare, Metabolic Technologies, University of Minnesota
NCT04734951N/ADec 31, 2021Government of Mexico, National Institute of Rehabilitation, Mexico
NCT05166499N/ANov 30, 2021The Cleveland Clinic
NCT05515900N/AOct 1, 2021American Heart Association, Augusta University
NCT04953936N/ASep 20, 2021Sichuan University
NCT05444959Phase 2/Phase 3 (Phase 3)Sep 10, 2021Charles University, National Science Centre, Poland, Poznan University
NCT04701463N/AJan 15, 2020University of Pavia
NCT04549610Phase 2/Phase 3 (Phase 3)Nov 1, 2019National Science Centre, Poland, Poznan University, University of Sao Paulo
NCT03892070N/AMar 1, 2019University of Roma La Sapienza
NCT03848741N/AFeb 28, 2019Metabolic Technologies, University of Illinois
NCT03827499N/AJan 30, 2019Universidad de Murcia
NCT03782155Phase 4Jan 7, 2019Hospital General de México, National Autonomous University of Mexico
NCT03234920N/ASep 25, 2015University of Roma La Sapienza
NCT02043171Phase 1Aug 1, 2014Iowa State University, Metabolic Technologies
NCT01270516N/AJan 1, 2014University of Kentucky
NCT01850251Phase 4Jun 1, 2013Abbott, University of Barcelona
Showing 20 of 20 trials
Page 1 / 1

Organizations

Research & Development (26)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Metabolic TechnologiesFor profit3122014
National Science Centre, PolandGovernment2012019
Poznan UniversityAcademic/Hospital2212019
Sun Yat-Sen UniversityAcademic/Hospital2212024
University of Roma La SapienzaAcademic/Hospital2212015
AbbottFor profit1012013
American Heart AssociationAcademic/Hospital1012021
Augusta UniversityAcademic/Hospital1112021
Charles UniversityAcademic/Hospital1012021
Gillette Children's Specialty HealthcareAcademic/Hospital1112022
Government of MexicoGovernment1012021
Hospital General de MéxicoAcademic/Hospital1012019
Iowa State UniversityAcademic/Hospital1012014
National Autonomous University of MexicoAcademic/Hospital1112019
National Institute of Rehabilitation, MexicoAcademic/Hospital1112021
Sichuan UniversityAcademic/Hospital1112021
Texas A&M UniversityAcademic/Hospital1112022
The Cleveland ClinicAcademic/Hospital1112021
Universidad de MurciaAcademic/Hospital1112019
University of BarcelonaAcademic/Hospital1112013
26 organizations
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