hydroxymethylbutyrate
β-Hydroxy β-methylbutyric acid (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS. In healthy adults, supplementation with HMB has been shown to increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce skeletal muscle damage from exercise, improve aerobic exercise performance, and expedite recovery from exercise. Medical reviews and meta-analyses indicate that HMB supplementation also helps to preserve or increase lean body mass and muscle strength in individuals experiencing age-related muscle loss. HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle tissue. No adverse effects from long-term use as a dietary supplement in adults have been found. — Wikipedia
Clinical trial activity
20 trials · 26 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2013 (NCT01850251)
Timeline
Indications
Approved for
Studied for
- Aerobiosis · Phase 2/Phase 3
- Bronchiectasis · Phase 2/Phase 3
- Diabetes Mellitus · Phase 4
- Diet · Phase 2/Phase 3
- Hip Fractures · Phase 4
- Protein Kinases · Phase 2/Phase 3
- Sarcopenia · Phase 1
- Sports · Phase 2/Phase 3
- Sports Medicine · Phase 2/Phase 3
- Sprains and Strains · Phase 2/Phase 3
- Wound Healing · Phase 4
Mechanism of action
- Serine/threonine-protein kinase mTORACTIVATOR
MTOR activator
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaΒ-Hydroxy β-methylbutyric acid ↗
- WikipediaBeta-Hydroxy beta-methylbutyric acid ↗
Also known as
- calcium beta-hydroxy-beta-methylbutyrate
- calcium beta-hydroxy-beta-methylbutyrate
- hydroxymethylbutyrate
- hydroxymethylbutyrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07142941 | N/A | Sep 1, 2025 | Sun Yat-Sen University |
| NCT07171593 | N/A | Mar 4, 2024 | Sun Yat-Sen University |
| NCT05877846 | N/A | Nov 1, 2023 | University of North Carolina at Chapel Hill |
| NCT05400733 | N/A | Jun 15, 2022 | Texas A&M University |
| NCT05384951 | N/A | May 15, 2022 | Gillette Children's Specialty Healthcare, Metabolic Technologies, University of Minnesota |
| NCT04734951 | N/A | Dec 31, 2021 | Government of Mexico, National Institute of Rehabilitation, Mexico |
| NCT05166499 | N/A | Nov 30, 2021 | The Cleveland Clinic |
| NCT05515900 | N/A | Oct 1, 2021 | American Heart Association, Augusta University |
| NCT04953936 | N/A | Sep 20, 2021 | Sichuan University |
| NCT05444959 | Phase 2/Phase 3 (Phase 3) | Sep 10, 2021 | Charles University, National Science Centre, Poland, Poznan University |
| NCT04701463 | N/A | Jan 15, 2020 | University of Pavia |
| NCT04549610 | Phase 2/Phase 3 (Phase 3) | Nov 1, 2019 | National Science Centre, Poland, Poznan University, University of Sao Paulo |
| NCT03892070 | N/A | Mar 1, 2019 | University of Roma La Sapienza |
| NCT03848741 | N/A | Feb 28, 2019 | Metabolic Technologies, University of Illinois |
| NCT03827499 | N/A | Jan 30, 2019 | Universidad de Murcia |
| NCT03782155 | Phase 4 | Jan 7, 2019 | Hospital General de México, National Autonomous University of Mexico |
| NCT03234920 | N/A | Sep 25, 2015 | University of Roma La Sapienza |
| NCT02043171 | Phase 1 | Aug 1, 2014 | Iowa State University, Metabolic Technologies |
| NCT01270516 | N/A | Jan 1, 2014 | University of Kentucky |
| NCT01850251 | Phase 4 | Jun 1, 2013 | Abbott, University of Barcelona |
Organizations
Research & Development (26)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Metabolic Technologies | For profit | 3 | 1 | 2 | 2014 |
| National Science Centre, Poland | Government | 2 | 0 | 1 | 2019 |
| Poznan University | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Sun Yat-Sen University | Academic/Hospital | 2 | 2 | 1 | 2024 |
| University of Roma La Sapienza | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Abbott | For profit | 1 | 0 | 1 | 2013 |
| American Heart Association | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Augusta University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Charles University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Gillette Children's Specialty Healthcare | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Government of Mexico | Government | 1 | 0 | 1 | 2021 |
| Hospital General de México | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Iowa State University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| National Autonomous University of Mexico | Academic/Hospital | 1 | 1 | 1 | 2019 |
| National Institute of Rehabilitation, Mexico | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Texas A&M University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| The Cleveland Clinic | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Universidad de Murcia | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Barcelona | Academic/Hospital | 1 | 1 | 1 | 2013 |