Hesperedin
Small moleculeexperimental
Hesperetin is the 4'-methoxy derivative of eriodictyol, a flavanone. The 7-O-glycoside of hesperetin, hesperidin, is a naturally occurring flavanone-glycoside, the main flavonoid in grapefruits, lemons, and sweet oranges. — Wikipedia
Clinical trial activity
12 trials · 22 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
8
Phase 3
4
Phase 4
1
Earliest trial started Mar 1, 2006 (NCT00330096)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetAntioxidant
Antioxidant
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)cc1O- Mol. weight
- 302.28 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaHesperetin ↗
- ChEMBLCHEMBL449317 ↗
- ChEMBLCHEMBL399121 ↗
Also known as
- 3',5,7-trihydroxy-4'-methoxyflavanone
- 3',5,7-trihydroxy-4'-methoxyflavanone
- 3',5,7-trihydroxy-4'-methoxyflavanone
- cyanidanon 4'-methyl ether 1626
- cyanidanon 4'-methyl ether 1626
- hesperetin
- hesperetin
- hesperetin
- hesperetin
- hesperetin
- hesperetin
- hesperetin
- (-)-hesperetin
- (-)-hesperetin
- hesperiden
- hesperiden
- hesperidin
- hesperidin
- hesperidin
- hesperidin
- hesperitin
- hesperitin
- hesperitin
- hesperitin
- nsc-31048
- nsc-31048
- (s)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
- (s)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
- (-)-(s)-hesperetin
- (-)-(s)-hesperetin
- yso2
- yso2
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06811220 | Phase 3 | Jan 27, 2025 | Alexandria University |
| NCT06672952 | N/A | Jan 1, 2025 | Increnovo, LLC, Lindenwood University |
| NCT02927483 | Phase 3 | Nov 1, 2016 | Opera CRO, Spitalul Universitar de Urgenta Elias, SunWave Pharma |
| NCT01773486 | Phase 2 | Jun 1, 2015 | University of Maryland |
| NCT02610491 | Phase 2 | Feb 1, 2015 | Maastricht University |
| NCT02095873 | Phase 1/Phase 2 (Phase 2) | May 1, 2014 | Technology Strategy Board, United Kingdom, Unilever, University of Warwick |
| NCT01654016 | Phase 4 | Aug 1, 2012 | Servier, University of Zagreb |
| NCT01477281 | Phase 3 | Feb 1, 2012 | Laboratório Teuto Brasileiro S/A |
| NCT01423019 | N/A | Oct 1, 2011 | Creighton University, Georgetown University, Integrative Health Technologies |
| NCT01881204 | N/A | Apr 1, 2011 | Nestle, Purdue University |
| NCT00914251 | Phase 2 | Nov 1, 2008 | University of Rome Tor Vergata |
| NCT00330096 | Phase 3 | Mar 1, 2006 | Government of France, Nestle, University Clermont Auvergne |
Showing 12 of 12 trials
Page 1 / 1
Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Nestle | For profit | 2 | 1 | 2 | 2006 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Creighton University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Georgetown University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Government of France | Government | 1 | 0 | 1 | 2006 |
| Increnovo, LLC | For profit | 1 | 0 | 1 | 2025 |
| Integrative Health Technologies | For profit | 1 | 1 | 1 | 2011 |
| Laboratório Teuto Brasileiro S/A | For profit | 1 | 1 | 1 | 2012 |
| Lindenwood University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Opera CRO | For profit | 1 | 0 | 1 | 2016 |
| Purdue University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Servier | For profit | 1 | 0 | 1 | 2012 |
| Spitalul Universitar de Urgenta Elias | Academic/Hospital | 1 | 0 | 1 | 2016 |
| SunWave Pharma | For profit | 1 | 1 | 1 | 2016 |
| Technology Strategy Board, United Kingdom | Government | 1 | 0 | 1 | 2014 |
| Unilever | For profit | 1 | 0 | 1 | 2014 |
| University Clermont Auvergne | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Maryland | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Rome Tor Vergata | Academic/Hospital | 1 | 1 | 1 | 2008 |
22 organizations
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