emicerfont
Small moleculeexperimental
Emicerfont (GW-876,008) is a drug developed by GlaxoSmithKline which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress, and activates the two corticotropin-releasing hormone receptors: CRF1 and CRF2. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress. — Wikipedia
Clinical trial activity
10 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2006 (NCT00429728)
Timeline
Indications
Mechanism of action
CRHR1 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1- Mol. weight
- 404.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEmicerfont ↗
- ChEMBLCHEMBL514270 ↗
Also known as
- emicerfont
- emicerfont
- emicerfont
- gw876008
- gw876008
- gw876008
- gw876008
- gw 876008
- gw-876008
- gw876008x
- gw876008x
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00511563 | Phase 2 | Aug 1, 2007 | GlaxoSmithKline |
| NCT00508911 | Phase 1 | Jun 1, 2007 | GlaxoSmithKline |
| NCT00555139 | Phase 1 | Mar 1, 2007 | GlaxoSmithKline |
| NCT00424697 | Phase 1 | Mar 1, 2007 | GlaxoSmithKline |
| NCT00423761 | Phase 1 | Dec 1, 2006 | GlaxoSmithKline |
| NCT00385099 | Phase 2 | Dec 1, 2006 | GlaxoSmithKline |
| NCT00376896 | Phase 1 | Nov 1, 2006 | GlaxoSmithKline |
| NCT00429728 | Phase 1 | Nov 1, 2006 | GlaxoSmithKline |
| NCT00397722 | Phase 2 | Nov 1, 2006 | GlaxoSmithKline |
| NCT00421707 | Phase 2 | Nov 1, 2006 | GlaxoSmithKline |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 10 | 10 | 2 | 2006 |
1 organizations
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