l-glutamic acid
Small moleculeexperimental
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery. — NCATS
Clinical trial activity
2 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Nov 2, 1999 (NCT00000768)
Timeline
Indications
Mechanism of action
- Unspecified targetOTHER
Nutritional support
- glutamateSupplementation
glutamate supplementation
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CCC(O)=O)C(O)=O- Mol. weight
- 147.1293 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS3KX376GY7L ↗
- ChEMBLCHEMBL575060 ↗
- ChEMBLCHEMBL1255943 ↗
Also known as
- (2s)-2-aminopentanedioic acid
- (2s)-2-aminopentanedioic acid
- 5-l-oxoproline
- 5-l-oxoproline
- 5-oxo-2-pyrrolidinecarboxylic acid
- 5-oxo-2-pyrrolidinecarboxylic acid
- 5-oxo-l-proline
- 5-oxo-l-proline
- 5-pyrrolidone-2-carboxylic acid
- 5-pyrrolidone-2-carboxylic acid
- e620
- e620
- gamma glutamic acid
- gamma glutamic acid
- glu
- glu
- glutamic acid
- glutamic acid
- glutamic acid
- glutamic acid
- glutamic acid
- glutamic acid
- glutamic acid
- glutamic acid hydrochloride
- glutamic acid hydrochloride
- glutamic acid hydrochloride
- l-glutamate
- l-glutamate
- l-glutamate
- l-glutamic acid
- l-glutamic acid
- l-glutamic acid
- l-glutamic acid hcl
- l-glutamic acid hcl
- l-glutaminic acid
- l-glutaminic acid
- muripsin
- (s)-2-aminopentanedioic acid
- (s)-2-aminopentanedioic acid
- (s)-glutamic acid
- (s)-glutamic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01826045 | Phase 2 | Jun 1, 2013 | BioLeaders Corporation, Catholic University of Korea, Cha Medical University, Keimyung University, Korea University, KwanDong University, MizMedi Hospital |
| NCT00000768 | Phase 1 | Nov 2, 1999 | National Institute of Allergy and Infectious Diseases (NIAID), Roche |
Showing 2 of 2 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioLeaders Corporation | For profit | 1 | 1 | 1 | 2013 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Cha Medical University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Keimyung University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| KwanDong University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| MizMedi Hospital | Academic/Hospital | 1 | 0 | 1 | 2013 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 1999 |
| Roche | For profit | 1 | 0 | 1 | 1999 |
9 organizations
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