fasiglifam
Small moleculeexperimental
Clinical trial activity
18 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
16
Phase 3
13
Phase 4
0
Earliest trial started Jan 1, 2009 (NCT00949091)
Timeline
Indications
Mechanism of action
- Free fatty acid receptor 1POSITIVE ALLOSTERIC MODULATOR
FFAR1 positive allosteric modulator
Potentiates insulin secretion in a glucose-dependent manner by activating FFAR1 expressed in pancreatic ß cells
Binds to a non-canonical site created between TM helices 3¿5 and the extracellular loop 2 regions
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1- Mol. weight
- 524.64 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1829174 ↗
Also known as
- (6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydro-1-benzofuran-3-yl)acetic acid hemihydrate
- fasiglifam
- fasiglifam
- fasiglifam
- fasiglifam
- fasiglifam
- tak-875
- tak-875
- tak-875
- tak-875
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02015780 | Phase 3 | Dec 1, 2013 | Takeda |
| NCT01982253 | Phase 2 | Oct 1, 2013 | Takeda |
| NCT01834274 | Phase 3 | Jun 1, 2013 | Takeda |
| NCT01829464 | Phase 3 | May 1, 2013 | Takeda |
| NCT01829477 | Phase 3 | Apr 1, 2013 | Takeda |
| NCT01647542 | Phase 3 | Oct 1, 2012 | Takeda |
| NCT01609582 | Phase 3 | Jun 1, 2012 | Takeda |
| NCT01585792 | Phase 3 | May 1, 2012 | Takeda |
| NCT01549964 | Phase 3 | Apr 1, 2012 | Takeda |
| NCT01433419 | Phase 3 | Jan 1, 2012 | Takeda |
| NCT01496443 | Phase 1 | Jan 1, 2012 | Takeda |
| NCT01481116 | Phase 3 | Jan 1, 2012 | Takeda |
| NCT01456195 | Phase 3 | Nov 1, 2011 | Takeda |
| NCT01433406 | Phase 3 | Oct 1, 2011 | Takeda |
| NCT01433393 | Phase 3 | Sep 12, 2011 | Takeda |
| NCT01414920 | Phase 2 | Aug 1, 2011 | Takeda |
| NCT01007097 | Phase 2 | Dec 1, 2009 | Takeda |
| NCT00949091 | Phase 1 | Jan 1, 2009 | Takeda |
Showing 18 of 18 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Takeda | For profit | 18 | 18 | 3 | 2009 |
1 organizations
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