ethyl chloride

Small moleculemarketed

Approved

Jun 1, 1847

Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste. Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries. — NCATS

Clinical trial activity

17 trials · 22 clinical orgs · 1 marketing orgs

Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
7

Earliest trial started Apr 1, 2012 (NCT01576770)

Timeline

1840s

  1. Jun 1, 1847

    Evidence of US Marketing

2010s

  1. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2020

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Approval history

  • approvedJun 1, 1847

Chemistry & pharmacology

Loading structure…

SMILES

CCCl
Mol. weight
64.514 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • chelen
  • chloroethane
  • chloroethane
  • chloroethane
  • chloroethane
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • ethyl chloride
  • monochloroethane
  • monochloroethane

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06920381Early Phase 1 (Phase 1)Jun 1, 2025University of California, Davis
NCT06651788N/AJan 1, 2025University of Chicago
NCT04422795Phase 4Feb 29, 2024Cornell University
NCT06274905N/AFeb 20, 2023University Hospital Waterford
NCT05568563N/AAug 1, 2022Altamash Institute of Dental Medicine
NCT05405452N/AJun 1, 2022University of Arizona
NCT04207710Phase 4Jan 31, 2020Gebauer Company, Henry Ford Health System
NCT04559906Phase 2Jan 11, 2020Riphah International University
NCT04635696Phase 4Jan 7, 2019ProMedica Health System
NCT03445780Phase 1Sep 30, 2018New York University
NCT03054740Phase 4Feb 27, 2017Aultman Health Foundation, Aultman Hospital
NCT03140293Early Phase 1 (Phase 1)Sep 1, 2016Icahn School of Medicine at Mount Sinai
NCT02770690Phase 4Apr 1, 2016Catholic University of Korea
NCT02592629Phase 4Feb 1, 2016Pennsylvania State University
NCT02587143N/AFeb 1, 2016Basque Country University, Bionorte, Osakidetza
NCT02499965N/AApr 1, 2015United States Army
NCT01576770Phase 4Apr 1, 2012University of Texas at Houston, Zars Pharma Inc.
Showing 17 of 17 trials
Page 1 / 1

Organizations

Research & Development (22)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Altamash Institute of Dental MedicineAcademic/Hospital1112022
Aultman Health FoundationAcademic/Hospital1112017
Aultman HospitalAcademic/Hospital1012017
Basque Country UniversityAcademic/Hospital1012016
BionorteAcademic/Hospital1112016
Catholic University of KoreaAcademic/Hospital1112016
Cornell UniversityAcademic/Hospital1112024
Gebauer CompanyFor profit1012020
Henry Ford Health SystemAcademic/Hospital1112020
Icahn School of Medicine at Mount SinaiAcademic/Hospital1112016
New York UniversityAcademic/Hospital1112018
OsakidetzaAcademic/Hospital1012016
Pennsylvania State UniversityAcademic/Hospital1112016
ProMedica Health SystemAcademic/Hospital1112019
Riphah International UniversityAcademic/Hospital1112020
United States ArmyGovernment1112015
University Hospital WaterfordAcademic/Hospital1112023
University of ArizonaAcademic/Hospital1112022
University of California, DavisAcademic/Hospital1112025
University of ChicagoAcademic/Hospital1112025
22 organizations
Page 1 / 2

Marketing (1)

OrganizationOrg typeRelationshipDate
MerckFor profitNDA