ethyl chloride
Approved
Jun 1, 1847
Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste. Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries. — NCATS
Clinical trial activity
17 trials · 22 clinical orgs · 1 marketing orgs
Earliest trial started Apr 1, 2012 (NCT01576770)
Timeline
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Approval history
- approvedJun 1, 1847
Chemistry & pharmacology
SMILES
CCCl- Mol. weight
- 64.514 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaChloroethane ↗
- NCATS46U771ERWK ↗
- ChEMBLCHEMBL46058 ↗
Also known as
- chelen
- chloroethane
- chloroethane
- chloroethane
- chloroethane
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- ethyl chloride
- monochloroethane
- monochloroethane
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06920381 | Early Phase 1 (Phase 1) | Jun 1, 2025 | University of California, Davis |
| NCT06651788 | N/A | Jan 1, 2025 | University of Chicago |
| NCT04422795 | Phase 4 | Feb 29, 2024 | Cornell University |
| NCT06274905 | N/A | Feb 20, 2023 | University Hospital Waterford |
| NCT05568563 | N/A | Aug 1, 2022 | Altamash Institute of Dental Medicine |
| NCT05405452 | N/A | Jun 1, 2022 | University of Arizona |
| NCT04207710 | Phase 4 | Jan 31, 2020 | Gebauer Company, Henry Ford Health System |
| NCT04559906 | Phase 2 | Jan 11, 2020 | Riphah International University |
| NCT04635696 | Phase 4 | Jan 7, 2019 | ProMedica Health System |
| NCT03445780 | Phase 1 | Sep 30, 2018 | New York University |
| NCT03054740 | Phase 4 | Feb 27, 2017 | Aultman Health Foundation, Aultman Hospital |
| NCT03140293 | Early Phase 1 (Phase 1) | Sep 1, 2016 | Icahn School of Medicine at Mount Sinai |
| NCT02770690 | Phase 4 | Apr 1, 2016 | Catholic University of Korea |
| NCT02592629 | Phase 4 | Feb 1, 2016 | Pennsylvania State University |
| NCT02587143 | N/A | Feb 1, 2016 | Basque Country University, Bionorte, Osakidetza |
| NCT02499965 | N/A | Apr 1, 2015 | United States Army |
| NCT01576770 | Phase 4 | Apr 1, 2012 | University of Texas at Houston, Zars Pharma Inc. |
Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Altamash Institute of Dental Medicine | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Aultman Health Foundation | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Aultman Hospital | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Basque Country University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Bionorte | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Catholic University of Korea | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Gebauer Company | For profit | 1 | 0 | 1 | 2020 |
| Henry Ford Health System | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2016 |
| New York University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Osakidetza | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Pennsylvania State University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| ProMedica Health System | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Riphah International University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| United States Army | Government | 1 | 1 | 1 | 2015 |
| University Hospital Waterford | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Arizona | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of California, Davis | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Chicago | Academic/Hospital | 1 | 1 | 1 | 2025 |
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Merck | For profit | NDA | — |