bexagliflozin

Trade name: Brenzavvy

Small moleculeapproved

Approved

Jan 20, 2023

Clinical trial activity

18 trials · 4 clinical orgs · 1 marketing orgs

Phase 1
8
Phase 2
8
Phase 3
8
Phase 4
0

Earliest trial started Dec 1, 2009 (NCT01029704)

Timeline

2000s

  1. Jan 1, 2009

    Theracos — Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2015

    Theracos — Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2016

    Theracos — Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 20, 2023

    Theracos — Earliest FDA Approval

  2. Jan 20, 2023

    Theracos — Marketing Organization

  3. Jan 20, 2023

    Theracos — NDA Secondary Org

  4. Jan 20, 2023

    Theracos — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedJan 20, 2023

Chemistry & pharmacology

Loading structure…

SMILES

OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OCCOC4CC4)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
Mol. weight
464.94 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • bexagliflozin
  • bexagliflozin
  • bexagliflozin
  • bexagliflozin
  • egt0001442
  • egt0001442
  • egt-0001442
  • egt-0001442
  • egt-1442
  • egt-1442
  • thr-1442
  • thr-1442

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05369078Phase 1Dec 1, 2021Newsoara Biopharma Co., Ltd.
NCT03417076Phase 1Aug 1, 2018Harvard University, Theracos
NCT03557658Phase 1Jul 26, 2018Theracos
NCT03259789Phase 3Nov 28, 2017Theracos
NCT03514641Phase 2/Phase 3 (Phase 3)Oct 18, 2017Harvard University, Theracos
NCT03296800Phase 1Sep 27, 2017Harvard University, Theracos
NCT03115112Phase 3Aug 1, 2017Theracos
NCT03197324Phase 1Jul 3, 2017Harvard University, Theracos
NCT03167411Phase 1Jun 20, 2017Harvard University, Theracos
NCT02956044Phase 1Nov 1, 2016Harvard University, Theracos
NCT02836873Phase 3Sep 1, 2016Harvard University, Theracos
NCT02769481Phase 3Aug 1, 2016Theracos
NCT02820298Phase 1Jun 1, 2016Davita Clinical Research, Theracos
NCT02715258Phase 3Mar 1, 2016Theracos
NCT02558296Phase 3Oct 1, 2015Theracos
NCT02390050Phase 2/Phase 3 (Phase 3)May 1, 2015Theracos
NCT01377844Phase 2Dec 1, 2011Harvard University, Theracos
NCT01029704Phase 2Dec 1, 2009Harvard University, Theracos
Showing 18 of 18 trials
Page 1 / 1

Organizations

Research & Development (4)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
TheracosFor profit171732009
Harvard UniversityAcademic/Hospital9032009
Davita Clinical ResearchFor profit1012016
Newsoara Biopharma Co., Ltd.For profit1112021
4 organizations
Page 1 / 1

Marketing (3)

OrganizationOrg typeRelationshipDate
TheracosFor profitMKTGJan 20, 2023
TheracosFor profitNDA2Jan 20, 2023
TheracosFor profitNDAJan 20, 2023