bq-123
Peptideexperimental
Clinical trial activity
17 trials · 13 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 1998 (NCT00115583)
Timeline
Indications
Studied for
- Cardiovascular Diseases · Phase 1
- Coronary Artery Bypass · Phase 2
- Coronary Artery Disease · Phase 2
- Coronary Vessels · Phase 1
- Endothelins · Phase 1
- Heart Disease Risk Factors · Phase 1
- Heart Failure · Phase 1
- Hypertension · Phase 1
- Hypertension, Pulmonary · Phase 2
- Metabolic Syndrome · Phase 1
- Multiple System Atrophy · Phase 1
- Myocardial Reperfusion Injury · Phase 2
- Proteinuria · Phase 1
- Pulmonary Disease, Chronic Obstructive · Phase 1
- Pure Autonomic Failure · Phase 1
- Renal Insufficiency, Chronic · Phase 1
- ST Elevation Myocardial Infarction · Phase 2
- Vascular Resistance · Phase 1
- Vasoconstriction · Phase 1
Mechanism of action
- Endothelin receptor ET-AANTAGONIST
Endothelin receptor ET-A antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O- Mol. weight
- 610.71 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL314691 ↗
- ChEMBLCHEMBL1269102 ↗
Also known as
- bq123
- bq123
- bq123
- bq 123
- bq 123
- bq 123
- bq-123
- bq-123
- bq-123
- bq-123
- cyclo(d-alpha-aspartyl-l-prolyl-d-valyl-l-leucyl-d-tryptophyl)
- cyclo(d-trp-d-asp-pro-d-val-leu)
- cyclo(trp-asp-pro-val-leu)
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03679780 | Phase 1 | Oct 1, 2018 | University of Texas, Arlington |
| NCT04907838 | N/A | May 1, 2018 | University of Southern Denmark, University of Texas, Arlington |
| NCT02936687 | Phase 1 | Jan 31, 2017 | University of Wisconsin |
| NCT02062346 | N/A | Aug 1, 2016 | British Heart Foundation, University of Edinburgh |
| NCT02124824 | Early Phase 1 (Phase 1) | Sep 1, 2014 | Department of Veteran Affairs, University of Utah |
| NCT02086253 | N/A | Feb 1, 2014 | Rouen Normandy University |
| NCT01658410 | Phase 2 | Jul 1, 2012 | University of Vienna |
| NCT00915070 | N/A | Oct 1, 2010 | University of Vienna |
| NCT01119417 | Phase 1 | May 1, 2010 | Vanderbilt University |
| NCT02966665 | Phase 1 | Sep 1, 2008 | Department of Veteran Affairs, University of Utah |
| NCT00745693 | N/A | Mar 1, 2008 | Umea University, University of Edinburgh |
| NCT00502528 | Phase 2 | May 1, 2007 | University of Vienna |
| NCT00722215 | Phase 1 | May 1, 2006 | British Heart Foundation, University of Edinburgh |
| NCT00586820 | Phase 2 | May 1, 2005 | Mayo Clinic |
| NCT00427232 | Phase 1 | May 1, 2003 | University of Vienna |
| NCT00759408 | Phase 2 | Feb 1, 1999 | Harvard University |
| NCT00115583 | N/A | Nov 1, 1998 | Harvard University |
Showing 17 of 17 trials
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Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Vienna | Academic/Hospital | 4 | 4 | 3 | 2003 |
| University of Edinburgh | Academic/Hospital | 3 | 3 | 2 | 2006 |
| British Heart Foundation | Academic/Hospital | 2 | 0 | 2 | 2006 |
| Department of Veteran Affairs | Government | 2 | 1 | 1 | 2008 |
| Harvard University | Academic/Hospital | 2 | 2 | 2 | 1998 |
| University of Texas, Arlington | Academic/Hospital | 2 | 1 | 2 | 2018 |
| University of Utah | Academic/Hospital | 2 | 1 | 1 | 2008 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2005 |
| Rouen Normandy University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Umea University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Southern Denmark | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Wisconsin | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2010 |
13 organizations
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