vofopitant
Small moleculeexperimental
Vofopitant (GR205171) is a drug which acts as an NK1 receptor antagonist. It has antiemetic effects as with other NK1 antagonists, and also shows anxiolytic actions in animals. It was studied for applications such as the treatment of social phobia and post-traumatic stress disorder, but did not prove sufficiently effective to be marketed. — Wikipedia
Clinical trial activity
3 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Sep 1, 2006 (NCT00383786)
Timeline
Indications
Mechanism of action
- Neurokinin 1 receptorANTAGONIST
TACR1 antagonist
Discontinueddue to lack of efficacy.
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1- Mol. weight
- 432.45 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaVofopitant ↗
- ChEMBLCHEMBL522302 ↗
Also known as
- gr205171
- gr205171
- gr205171
- gr 205171
- gr-205171
- gr-205171
- gr-205171
- gr 226206
- l-796,325
- n-((2-methoxy-5-(5-(trifluoromethyl)-1h-tetrazol-1-yl)phenyl)methyl)-2-phenyl-3-piperidinamine
- vofopitant
- vofopitant
- vofopitant
- vofopitant
- vofopitant
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00907985 | Phase 1 | May 1, 2009 | GlaxoSmithKline |
| NCT00606697 | Phase 2 | Dec 1, 2007 | GlaxoSmithKline |
| NCT00383786 | Phase 2 | Sep 1, 2006 | Baylor University, Icahn School of Medicine at Mount Sinai, National Institute of Mental Health (NIMH) |
Showing 3 of 3 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 2 | 2 | 2 | 2007 |
| Baylor University | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 0 | 1 | 2006 |
| National Institute of Mental Health (NIMH) | Government | 1 | 0 | 1 | 2006 |
4 organizations
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