dimethyl sulfoxide
Trade name: rimso
Small moleculeapproved
Approved
Apr 4, 1978
Dimethyl sulfoxide (DMSO) is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of interstitial cystitis and to certain experimental applications. In medicine, DMSO is also used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory, and an antioxidant. — NCATS
Clinical trial activity
14 trials · 16 clinical orgs · 1 marketing orgs
Phase 1
4
Phase 2
4
Phase 3
3
Phase 4
1
Earliest trial started Nov 1, 2004 (NCT00118313)
Timeline
Indications
Studied for
- Breast Diseases · Phase 2/Phase 3
- Breast Neoplasms · Phase 2
- Cystitis, Interstitial · Phase 4
- Dentist-Patient Relations · Phase 1
- Dimethyl Sulfoxide · Phase 2/Phase 3
- Melanoma · Phase 1
- Orthognathic Surgical Procedures · Phase 2/Phase 3
- Radiodermatitis · Phase 2
- Urinary Bladder · Phase 3
- Urinary Bladder Diseases · Phase 2
- Urinary Bladder, Overactive · Phase 3
- Urinary Incontinence · Phase 3
- Urinary Incontinence, Urge · Phase 3
Mechanism of action
- Unspecified targetOTHER
Unknown
Approval history
- approvedApr 4, 1978
Chemistry & pharmacology
Loading structure…
SMILES
C[S+](C)[O-]- Mol. weight
- 78.133 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaDimethyl sulfoxide ↗
- NCATSYOW8V9698H ↗
- ChEMBLCHEMBL504 ↗
Also known as
- (ch3)2so
- (ch3)2so
- demavet
- demsodrox
- dimethyli sulfoxidum
- dimethyli sulfoxidum
- dimethyl sulfone
- dimethyl sulfone, 13c-labeled
- dimethylsulfoxid
- dimethylsulfoxid
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethyl sulfoxide
- dimethylsulfoxyde
- dimethylsulfoxyde
- dimethyl sulfur oxide
- dimethyl sulfur oxide
- dimethyl sulphoxide
- dimethyl sulphoxide
- dimetil sulfoxido
- dimetil sulfoxido
- dmso
- dmso
- dmso
- dmso
- dmso
- domoso
- domoso
- infiltrina
- infiltrina
- methylsulfinylmethane
- methylsulfinylmethane
- methyl sulfoxide
- rimso 50
- rimso 50
- rimso-50
- rimso-50
- rimso-50
- s(o)me2
- s(o)me2
- sq-9453
- sq-9453
- sulfinylbis(methane)
- sulfinylbis(methane)
- syntexan
- syntexan
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07196618 | N/A | Sep 30, 2025 | Al Azhar University |
| NCT05090085 | N/A | Dec 1, 2021 | Delta University for Science and Technology, University of Turku |
| NCT05560919 | Phase 2/Phase 3 (Phase 3) | Sep 20, 2021 | Tishreen University |
| NCT04492306 | N/A | Nov 17, 2020 | Cairo University, University of Turku |
| NCT03716583 | Phase 2 | Apr 30, 2019 | University of Copenhagen |
| NCT03103594 | Early Phase 1 (Phase 1) | Aug 1, 2015 | Society for Urodynamics and Female Urology, University of Pennsylvania |
| NCT02206477 | Phase 2/Phase 3 (Phase 3) | Aug 1, 2014 | Tel Aviv University |
| NCT02337192 | Phase 1 | Jan 1, 2014 | University of Sao Paulo |
| NCT05223244 | Phase 4 | Oct 1, 2011 | University of Chicago |
| NCT01069263 | N/A | Feb 1, 2010 | Hebrew University, Tel Aviv University |
| NCT00667095 | Phase 3 | Apr 1, 2008 | Mayo Clinic |
| NCT00317070 | Phase 2 | Apr 1, 2006 | Government of Canada |
| NCT00583219 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2006 | Mayo Clinic |
| NCT00118313 | Phase 1 | Nov 1, 2004 | National Cancer Institute (NCI), University of Virginia |
Showing 14 of 14 trials
Page 1 / 1
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Mayo Clinic | Academic/Hospital | 2 | 2 | 2 | 2006 |
| Tel Aviv University | Academic/Hospital | 2 | 2 | 2 | 2010 |
| University of Turku | Academic/Hospital | 2 | 1 | 1 | 2020 |
| Al Azhar University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Delta University for Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Government of Canada | Government | 1 | 1 | 1 | 2006 |
| Hebrew University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2004 |
| Society for Urodynamics and Female Urology | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Tishreen University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Chicago | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Pennsylvania | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Sao Paulo | Academic/Hospital | 1 | 1 | 1 | 2014 |
| University of Virginia | Academic/Hospital | 1 | 1 | 1 | 2004 |
16 organizations
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