dimenhydrinate
Small moleculeapproved
Approved
Jun 1, 1949
Dyme, or Dymae, was a town and polis (city-state) of ancient Achaea, and the most westerly of the 12 Achaean cities, from which circumstance it is said to have derived its name. The location of Dyme is near the modern Kato Achaia. — Wikipedia
Clinical trial activity
10 trials · 12 clinical orgs · 9 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
3
Phase 4
4
Earliest trial started Apr 1, 2005 (NCT00124787)
Timeline
1940s
- Jun 1, 1949
Earliest FDA Approval
1970s
- May 31, 1972
Alta Pharma — Marketing Organization
- Jan 29, 1974
Teva — Marketing Organization
- Aug 18, 1975
American Home Products — Marketing Organization
- Sep 13, 1976
Baxalta — Marketing Organization
- Sep 13, 1976
Baxter — Marketing Organization
- Dec 19, 1977
Nexgen Pharma, Inc — Marketing Organization
1980s
- Dec 21, 1981
Watson Pharmaceuticals — Marketing Organization
Indications
Approved for
Mechanism of action
- Histamine H1 receptorANTAGONIST
HRH1 antagonist
Approval history
- approvedJun 1, 1949
Chemistry & pharmacology
Loading structure…
SMILES
CN1C2=C(N=C(Cl)N2)C(=O)N(C)C1=O.CN(C)CCOC(C3=CC=CC=C3)C4=CC=CC=C4- Mol. weight
- 469.964 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
No
Sources
- WikipediaDyme ↗
- NCATSJB937PER5C ↗
- ChEMBLCHEMBL1200406 ↗
- WikipediaDimenhydrinate ↗
Also known as
- 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione - 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1)
- 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione - 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1)
- andramine
- antemin
- antemin
- benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
- benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
- beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine
- beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine
- chloranautine
- chloranautine
- chloranautine
- diamarin
- dimenhidrinato
- dimenhidrinato
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinate
- dimenhydrinatum
- dimenhydrinatum
- diphenhydramine 8-chlorotheophyllinate
- diphenhydramine 8-chlorotheophyllinate
- diphenhydramine 8-chlorotheophyllinate
- diphenhydramine 8-chlorotheophylline
- diphenhydramine 8-chlorotheophylline
- diphenhydramine theoclate
- diphenhydramine theoclate
- diphenhydrinate
- diphenhydrinate
- diphenhydrinate
- dramamine
- dramamine
- dramamine
- dramamine
- dyme
- menhydrinate
- n,n-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate
- n,n-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate
- (o-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
- (o-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
- o-benzhydryldimethylaminoethanol 8-chlorotheophyllinate
- o-benzhydryldimethylaminoethanol 8-chlorotheophyllinate
- theohydramine
- vertigo-vomex s
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04835116 | Phase 4 | Apr 11, 2019 | Government of India, Government of Pakistan |
| NCT05590936 | N/A | Jan 1, 2018 | University of Thessaly |
| NCT02112578 | Phase 3 | Nov 1, 2016 | Apsen Farmaceutica S.A., CCBR Clinical Research |
| NCT01890538 | Phase 4 | Jun 1, 2013 | Kocaeli University |
| NCT02253524 | Phase 4 | Nov 1, 2012 | Pamukkale University |
| NCT00791960 | N/A | Nov 1, 2008 | Icahn School of Medicine at Mount Sinai |
| NCT00596492 | Phase 3 | May 1, 2008 | Aqumen Biopharmaceuticals, N.A. |
| NCT01543945 | Phase 2 | Mar 1, 2008 | Prince of Songkla University |
| NCT00596583 | Phase 3 | Apr 1, 2007 | Aqumen Biopharmaceuticals, N.A. |
| NCT00124787 | Phase 4 | Apr 1, 2005 | Canadian Association of Emergency Physicians, University of Montreal |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aqumen Biopharmaceuticals, N.A. | For profit | 2 | 2 | 1 | 2007 |
| Apsen Farmaceutica S.A. | For profit | 1 | 1 | 1 | 2016 |
| Canadian Association of Emergency Physicians | Academic/Hospital | 1 | 0 | 1 | 2005 |
| CCBR Clinical Research | For profit | 1 | 0 | 1 | 2016 |
| Government of India | Government | 1 | 0 | 1 | 2019 |
| Government of Pakistan | Government | 1 | 1 | 1 | 2019 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Kocaeli University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Pamukkale University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Prince of Songkla University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Montreal | Academic/Hospital | 1 | 1 | 1 | 2005 |
| University of Thessaly | Academic/Hospital | 1 | 1 | 1 | 2018 |
12 organizations
Page 1 / 1
Marketing (9)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alta Pharma | For profit | MKTG | May 31, 1972 |
| American Home Products | For profit | MKTG | Aug 18, 1975 |
| Baxalta | For profit | MKTG | Sep 13, 1976 |
| Baxter | For profit | MKTG | Sep 13, 1976 |
| Fresenius | For profit | MKTG | Jun 23, 2004 |
| Heather Pharma | For profit | MKTG | — |
| Nexgen Pharma, Inc | For profit | MKTG | Dec 19, 1977 |
| Teva | For profit | MKTG | Jan 29, 1974 |
| Watson Pharmaceuticals | For profit | MKTG | Dec 21, 1981 |