dalcetrapib
Small moleculeexperimental
DalCor is currently conducting the Dal-GenE-2 confirmatory trial with dalcetrapib and placebo in North America under a Special Protocol Assessment (SPA) agreement with the U.S. Food and Drug Administration (FDA). — Wikipedia
Clinical trial activity
14 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
12
Phase 3
6
Phase 4
0
Earliest trial started Jul 1, 2005 (NCT00697203)
Timeline
Indications
Mechanism of action
- Cholesteryl ester transfer proteinINHIBITOR
CETP inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21- Mol. weight
- 406.39 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDalcetrapib ↗
- ChEMBLCHEMBL313006 ↗
- ChEMBLCHEMBL1090089 ↗
Also known as
- dalcetrapib
- dalcetrapib
- dalcetrapib
- dalcetrapib
- dalcetrapib
- jtt-705
- ro-4607381
- ro-4607381
- s-(2-((1-(2-ethylbutyl)cyclohexane)carbonylamino)phenyl) 2-methylpropanethioate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05918861 | Phase 3 | Oct 3, 2023 | DalCor Pharmaceuticals, The Montreal Health Innovations Coordinating Center |
| NCT04676867 | Phase 2 | Dec 31, 2020 | Covance, DalCor Pharmaceuticals, The Montreal Health Innovations Coordinating Center |
| NCT02525939 | Phase 3 | Apr 1, 2016 | DalCor Pharmaceuticals, Medpace, Inc., Roche, The Montreal Health Innovations Coordinating Center |
| NCT01516541 | Phase 3 | Jan 1, 2012 | Roche |
| NCT01476267 | Phase 1 | Oct 1, 2011 | Roche |
| NCT01363999 | Phase 1 | Jun 1, 2011 | Roche |
| NCT01323153 | Phase 3 | Mar 1, 2011 | Roche |
| NCT01059682 | Phase 3 | Jan 1, 2010 | Roche |
| NCT00658515 | Phase 3 | Apr 1, 2008 | Roche |
| NCT00655473 | Phase 2 | Mar 1, 2008 | Roche |
| NCT00655538 | Phase 2 | Feb 1, 2008 | Roche |
| NCT00400439 | Phase 2 | Jan 1, 2007 | Roche |
| NCT00353522 | Phase 2 | Jul 1, 2006 | Roche |
| NCT00697203 | Phase 2 | Jul 1, 2005 | Roche |
Showing 14 of 14 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Roche | For profit | 12 | 11 | 3 | 2005 |
| DalCor Pharmaceuticals | For profit | 3 | 3 | 2 | 2016 |
| The Montreal Health Innovations Coordinating Center | For profit | 3 | 0 | 2 | 2016 |
| Covance | For profit | 1 | 0 | 1 | 2020 |
| Medpace, Inc. | For profit | 1 | 0 | 1 | 2016 |
5 organizations
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