odanacatib
Small moleculeexperimental
Odanacatib is an investigational treatment for osteoporosis and bone metastasis. It is an inhibitor of cathepsin K, an enzyme involved in bone resorption. — Wikipedia
Clinical trial activity
21 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
13
Phase 3
7
Phase 4
0
Earliest trial started Jun 1, 2004 (NCT00863590)
Timeline
Indications
Mechanism of action
- Cathepsin KINHIBITOR
CTSK inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1- Mol. weight
- 525.57 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaOdanacatib ↗
- ChEMBLCHEMBL481611 ↗
Also known as
- l-1037536
- mk0822
- mk0822
- mk-0822
- mk-0822
- mk-0822
- mk-0822
- odanacatib
- odanacatib
- odanacatib
- odanacatib
- odanacatib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01803607 | Phase 3 | Mar 1, 2013 | Merck |
| NCT01630616 | Phase 1 | Mar 1, 2013 | Merck |
| NCT01552122 | Phase 3 | May 1, 2012 | Merck |
| NCT01512693 | Phase 1 | Feb 1, 2012 | Merck |
| NCT01512667 | Phase 1 | Jan 1, 2012 | Merck |
| NCT01120600 | Phase 3 | Jun 1, 2010 | Merck |
| NCT01068262 | Phase 1 | Dec 8, 2009 | Merck |
| NCT00885170 | Phase 2 | Apr 1, 2009 | Merck |
| NCT00729183 | Phase 3 | Oct 1, 2008 | Merck |
| NCT00691899 | Phase 3 | Sep 1, 2008 | Merck |
| NCT00692458 | Phase 3 | Sep 1, 2008 | Merck |
| NCT00620113 | Phase 2 | Dec 1, 2007 | Merck |
| NCT00529373 | Phase 3 | Sep 1, 2007 | Merck |
| NCT00399802 | Phase 2 | Nov 1, 2006 | Merck |
| NCT00397683 | Phase 2 | Oct 1, 2006 | Merck |
| NCT00242476 | Phase 2 | Sep 1, 2005 | Merck |
| NCT00112437 | Phase 2 | Jun 1, 2005 | Merck |
| NCT00863525 | Phase 1 | Nov 1, 2004 | Merck |
| NCT00770159 | Phase 1 | Nov 1, 2004 | Merck |
| NCT00769418 | Phase 1 | Sep 1, 2004 | Merck |
Showing 20 of 21 trials
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Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merck | For profit | 21 | 21 | 3 | 2004 |
1 organizations
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