chlorpropamide

Trade name: diabinese

Small moleculeapproved

Approved

Oct 28, 1958

Chlorpropamide (DIABINESE®), is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. It appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which chlorpropamide (DIABINESE®) lowers blood glucose during long-term administration has not been clearly established. Extra-pancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. While chlorpropamide is a sulfonamide derivative, it is devoid of antibacterial activity. Chlorpropamide (DIABINESE®) may also prove effective in controlling certain patients who have experienced primary or secondary failure to other sulfonylurea agent. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 14 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Oct 28, 1958
Pfizer — Earliest FDA Approval
Oct 28, 1958
Pfizer — NDA Organization

1980s

Jul 10, 1980
Sandoz — Marketing Organization
Feb 27, 1984
Par Pharmaceuticals — Marketing Organization
Jun 1, 1984
Mylan — Marketing Organization
Jun 1, 1984
PHARMOBEDIENT — Marketing Organization
Aug 31, 1984
Rising Pharmaceuticals — Marketing Organization
Aug 31, 1984
Aurobindo Pharma — Marketing Organization
Sep 17, 1984
Superpharm — Marketing Organization
Sep 24, 1984
Watson Pharmaceuticals — Marketing Organization
Sep 26, 1984
Teva — Marketing Organization
Oct 11, 1984
Ani Pharmaceuticals — Marketing Organization

Indications

Approved for

Mechanism of action

Sulfonylurea receptor 1, Kir6.2BLOCKER
Sulfonylurea receptor 1, Kir6.2 blocker
- ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) ↗
- ATP-binding cassette sub-family C member 8 (ABCC8) ↗
- Sulfonylurea receptor 1
- Potassium channel, inwardly rectifying, subfamily J, member 11

Approval history

approvedPriority reviewOct 28, 1958

Chemistry & pharmacology

Loading structure…

SMILES

CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1

Mol. weight: 276.74 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

1-(p-chlorobenzenesulfonyl)-3-propylurea
1-(p-chlorobenzenesulfonyl)-3-propylurea
1-(p-chlorophenylsulfonyl)-3-propylurea
1-(p-chlorophenylsulfonyl)-3-propylurea
1-propyl-3-(p-chlorobenzenesulfonyl)urea
1-propyl-3-(p-chlorobenzenesulfonyl)urea
4-chloro-n-((propylamino)carbonyl)benzenesulfonamide
4-chloro-n-((propylamino)carbonyl)benzenesulfonamide
4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide
4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide
chlorodiabina
chloronase
chloropropamide
chlorpropamid
chlorpropamid
chlorpropamid
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamide
chlorpropamidum
chlorpropamidum
clorpropamida
clorpropamida
diabemide
diabinese
diabinese
diabinese
diabineses
glucamide
glucamide
glymese
melitase
melitase
n-(4-chlorophenylsulfonyl)-n'-propylurea
n-(4-chlorophenylsulfonyl)-n'-propylurea
n-(p-chlorobenzenesulfonyl)-n'-propylurea
n-(p-chlorobenzenesulfonyl)-n'-propylurea
n-propyl-n'-(p-chlorobenzenesulfonyl)urea
n-propyl-n'-(p-chlorobenzenesulfonyl)urea
n-propyl-n'-p-chlorophenylsulfonylcarbamide
n-propyl-n'-p-chlorophenylsulfonylcarbamide

Organizations

Marketing (15)

Organization	Org type	Relationship	Date
Ani Pharmaceuticals	For profit	SYN	Jun 26, 1981
Ani Pharmaceuticals	For profit	MKTG	Oct 11, 1984
Aurobindo Pharma	For profit	MKTG	Aug 31, 1984
DAVA Pharmaceuticals	For profit	MKTG	—
Halsey	For profit	MKTG	—
Mylan	For profit	MKTG	Jun 1, 1984
PHARMOBEDIENT	For profit	MKTG	Jun 1, 1984
Par Pharmaceuticals	For profit	MKTG	Feb 27, 1984
Pfizer	For profit	NDA	Oct 28, 1958
Rising Pharmaceuticals	For profit	MKTG	Aug 31, 1984
Sandoz	For profit	MKTG	Jul 10, 1980
Superpharm	For profit	MKTG	Sep 17, 1984
Teva	For profit	MKTG	Sep 26, 1984
Upsher-Smith Laboratories	For profit	MKTG	—
Watson Pharmaceuticals	For profit	MKTG	Sep 24, 1984