mdl 28574
Small moleculeexperimental
Clinical trial activity
9 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
8
Phase 3
0
Phase 4
0
Earliest trial started Nov 2, 1999 (NCT00002329)
Timeline
Indications
Mechanism of action
- Alpha-glucosidaseINHIBITOR
agl1 inhibitor
- Alpha glucosidaseINHIBITOR
Alpha glucosidase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCCC(=O)O[C@H]1CN2CC[C@H](O)[C@@H]2[C@@H](O)[C@@H]1O- Mol. weight
- 259.3 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL2110737 ↗
- ChEMBLCHEMBL2105801 ↗
Also known as
- 6-o-butanoylcastanospermine
- bucast
- butanoic acid, octahydro-1,7,8-trihydroxy-6-indolizinyl ester, (1s-(1alpha,6beta,7alpha,8beta,8abeta))-
- celgosivir
- celgosivir
- celgosivir
- celgosivir
- celgosivir hcl
- celgosivir hcl
- celgosivir hydrochloride
- celgosivir hydrochloride
- celgosivir hydrochloride
- mbi3253
- mbi 3253
- mbi-3253
- mdl 28574
- mdl 28,574
- mdl-28574
- mdl-28574a
- mdl-28574a
- mx3253
- mx 3253
- mx-3253
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02569827 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2017 | 60 Degrees Pharmaceuticals LLC, Duke University, Singapore General Hospital |
| NCT01619969 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2012 | Duke University, Singapore General Hospital |
| NCT00332176 | Phase 2 | Jun 1, 2006 | BioWest Therapeutics Inc |
| NCT00292084 | Phase 2 | Feb 1, 2006 | BioWest Therapeutics Inc |
| NCT00217139 | Phase 2 | Sep 1, 2005 | BioWest Therapeutics Inc |
| NCT00157534 | Phase 2 | Oct 1, 2004 | BioWest Therapeutics Inc |
| NCT00002150 | Phase 2 | Nov 2, 1999 | Hoechst Marion Roussel |
| NCT00002329 | Phase 1 | Nov 2, 1999 | Hoechst Marion Roussel |
| NCT00002151 | Phase 2 | Nov 2, 1999 | Hoechst Marion Roussel |
Showing 9 of 9 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioWest Therapeutics Inc | For profit | 4 | 4 | 1 | 2004 |
| Hoechst Marion Roussel | For profit | 3 | 3 | 2 | 1999 |
| Duke University | Academic/Hospital | 2 | 0 | 1 | 2012 |
| Singapore General Hospital | Academic/Hospital | 2 | 2 | 1 | 2012 |
| 60 Degrees Pharmaceuticals LLC | For profit | 1 | 0 | 1 | 2017 |
5 organizations
Page 1 / 1