cefotiam
Trade name: ceradon
Small moleculeapproved
Approved
Dec 30, 1988
Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). — NCATS
Clinical trial activity
2 trials · 7 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2016 (NCT02693951)
Timeline
Indications
Mechanism of action
- Bacterial penicillin-binding proteinINHIBITOR
Bacterial penicillin-binding protein inhibitor
- D-alanyl-D-alanine carboxypeptidase DacB (dacB) ↗
- Peptidoglycan D,D-transpeptidase FtsI (ftsI) ↗
- Penicillin-binding protein 1A (mrcA) ↗
- Penicillin-binding protein 1B (mrcB) ↗
- D-alanyl-D-alanine carboxypeptidase DacA (dacA) ↗
- Peptidoglycan D,D-transpeptidase MrdA (mrdA) ↗
- D-alanyl-D-alanine carboxypeptidase DacC (dacC) ↗
Approval history
- approvedDec 30, 1988
Chemistry & pharmacology
Loading structure…
SMILES
CN(C)CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1- Mol. weight
- 525.64 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1296 ↗
- WikipediaCefotiam ↗
- NCATS91W6Z2N718 ↗
- ChEMBLCHEMBL4303232 ↗
- ChEMBLCHEMBL1200589 ↗
Also known as
- (6r,7r)-7-[2-(2-amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1h-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6r,7r)-7-[2-(2-amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1h-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- abbott-48999
- abbott-48999
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam
- cefotiam hcl
- cefotiam hcl
- cefotiam hcl
- cefotiam hexetil
- cefotiam hexetil
- cefotiam hexetil
- cefotiam hexetil
- cefotiam hexetil hcl
- cefotiam hexetil hcl
- cefotiam hexetil hcl
- cefotiam hexetil hydrochloride
- cefotiam hydrochloride
- cefotiam hydrochloride
- cefotiam hydrochloride
- cefotiam hydrochloride
- cefotiamum
- cefotiamum
- ceradon
- ceradon
- cgp-14221/e
- cgp-14221/e
- ctm
- ctm
- pansporin
- pansporin
- pansporin
- sce-963
- sce-963
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03045783 | N/A | Dec 1, 2016 | Anhui College of Traditional Chinese Medicine, Capital Medical University, Fudan University, Jiao Tong University, Second People's Hospital of Lanzhou, Shandong Provincial Hospital, Wuhan University |
| NCT02693951 | N/A | Feb 1, 2016 | Fudan University |
Showing 2 of 2 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Fudan University | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Anhui College of Traditional Chinese Medicine | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Capital Medical University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Jiao Tong University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Second People's Hospital of Lanzhou | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Shandong Provincial Hospital | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Wuhan University | Academic/Hospital | 1 | 0 | 1 | 2016 |
7 organizations
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