buthionine sulfoximine
Small moleculeexperimental
Buthionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs. — Wikipedia
Clinical trial activity
3 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 1996 (NCT00002730)
Timeline
1990s
- Jan 1, 1996
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Gamma-glutamylcysteine synthetaseINHIBITOR
GCLC inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCCCS(=N)(=O)CCC(N)C(=O)O- Mol. weight
- 222.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaButhionine sulfoximine ↗
- ChEMBLCHEMBL1609891 ↗
- ChEMBLCHEMBL1256575 ↗
Also known as
- buthionine sulfoximine
- buthionine sulfoximine
- buthionine sulfoximine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00661336 | Phase 1 | Apr 1, 2008 | Duke University, National Cancer Institute (NCI) |
| NCT00005835 | Phase 1 | Aug 1, 2001 | National Cancer Institute (NCI), University of Chicago |
| NCT00002730 | Phase 1 | Jun 1, 1996 | National Cancer Institute (NCI), University of Southern California |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 3 | 1 | 1 | 1996 |
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Chicago | Academic/Hospital | 1 | 0 | 1 | 2001 |
| University of Southern California | Academic/Hospital | 1 | 1 | 1 | 1996 |
4 organizations
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