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bryostatin

Small moleculeexperimental

Bryostatins are a group of macrolide lactones from the marine organism Bugula neritina that were first collected and provided to JL Hartwell’s anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe. Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease. — Wikipedia

Clinical trial activity

44 trials · 32 clinical orgs · 0 marketing orgs

Phase 1
16
Phase 2
29
Phase 3
0
Phase 4
0

Earliest trial started Aug 1, 1996 (NCT00002725)

Timeline

1990s

  1. Jan 1, 1996

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 1997

    Earliest Phase 1 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)C[C@H]2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3C[C@H](OC(C)=O)C(C)(C)[C@](O)(C[C@@H]4C/C(=C/C(=O)OC)C[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3
Mol. weight
905.04 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • bryostatin
  • bryostatin
  • bryostatin 1
  • bryostatin 1
  • bryostatin-1

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06190912Phase 1Jun 26, 2024The Cleveland Clinic
NCT04538066Phase 2Aug 30, 2020National Institute on Aging (NIA), National Institutes of Health (NIH), Petros Pharmaceuticals
NCT03560245Phase 2Jun 20, 2018Petros Pharmaceuticals, Worldwide Clinical Trials
NCT02431468Phase 2Nov 1, 2015Petros Pharmaceuticals
NCT02269605Phase 1Sep 1, 2014Universidad Complutense de Madrid
NCT02221947Phase 1/Phase 2 (Phase 2)Jun 1, 2014Blanchette Rockefeller Neurosciences Insitute, California Clinical Trials, Petros Pharmaceuticals
NCT00606164Phase 2Apr 1, 2008Blanchette Rockefeller Neurosciences Insitute, West Virginia University
NCT00112476Phase 1Mar 1, 2005National Cancer Institute (NCI), Temple University
NCT00087425Phase 2Jul 1, 2004National Cancer Institute (NCI), National Institute on Aging (NIA)
NCT00058305Phase 2Mar 1, 2003Case Western Reserve University, National Cancer Institute (NCI)
NCT00032188Phase 2Jan 1, 2002National Cancer Institute (NCI), University of Chicago
NCT00031694Phase 2Jan 1, 2002National Cancer Institute (NCI), Yeshiva University
NCT00022555Phase 1Nov 1, 2001AIDS Malignancy Consortium, National Cancer Institute (NCI)
NCT00017342Phase 2Jul 1, 2001National Cancer Institute (NCI), Virginia Commonwealth University
NCT00012376Phase 1Mar 1, 2001Johns Hopkins University, National Cancer Institute (NCI)
NCT00006389Phase 2Oct 1, 2000National Cancer Institute (NCI), University of Southern California
NCT00006942Phase 2Oct 1, 2000City of Hope National Medical Center, National Cancer Institute (NCI)
NCT00006022Phase 1Sep 1, 2000National Cancer Institute (NCI), Virginia Commonwealth University
NCT00005965Phase 2Aug 1, 2000Icahn School of Medicine at Mount Sinai, National Cancer Institute (NCI)
NCT00006081Phase 2Jun 1, 2000National Cancer Institute (NCI), University of Texas at Houston
Showing 20 of 44 trials
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Organizations

Research & Development (32)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government341121996
Wayne State UniversityAcademic/Hospital7721996
Petros PharmaceuticalsFor profit4412014
Virginia Commonwealth UniversityAcademic/Hospital4421997
Cornell UniversityAcademic/Hospital3321998
National Institute on Aging (NIA)Government3221999
Blanchette Rockefeller Neurosciences InsituteAcademic/Hospital2112008
Case Western Reserve UniversityAcademic/Hospital2021998
Temple UniversityAcademic/Hospital2021999
University of ChicagoAcademic/Hospital2112000
University of Texas at HoustonAcademic/Hospital2111996
AIDS Malignancy ConsortiumAcademic/Hospital1012001
California Clinical TrialsFor profit1012014
Cancer Research UKAcademic/Hospital1111999
City of Hope National Medical CenterAcademic/Hospital1012000
Georgetown UniversityAcademic/Hospital1111997
Harvard UniversityAcademic/Hospital1111997
Icahn School of Medicine at Mount SinaiAcademic/Hospital1112000
Johns Hopkins UniversityAcademic/Hospital1012001
National Institutes of Health (NIH)Government1012020
32 organizations
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