bms-214662
Small moleculeexperimental
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Jul 1, 1999 (NCT00004877)
Timeline
1990s
- Jan 1, 1999
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Anemia, Refractory · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Leukemia, Myeloid, Chronic-Phase · Phase 1
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 1
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
Mechanism of action
- Protein farnesyltransferaseINHIBITOR
Protein farnesyltransferase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
N#Cc1ccc2c(c1)CN(S(=O)(=O)c1cccs1)[C@H](Cc1ccccc1)CN2Cc1c[nH]cn1- Mol. weight
- 489.63 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL351706 ↗
Also known as
- 7-cyano-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1h-1,4-benzodiazepine
- bms 214662
- bms-214662
- bms-214662
- bms-214662
- bms-214662
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00022529 | Phase 1 | Jul 1, 2001 | National Cancer Institute (NCI), Temple University |
| NCT00006018 | Phase 1 | Jul 1, 2000 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00006242 | Phase 1 | Jul 1, 2000 | Harvard University, National Cancer Institute (NCI) |
| NCT00005973 | Phase 1 | Apr 1, 2000 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT00006213 | Phase 1 | Apr 1, 2000 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT00004877 | Phase 1 | Jul 1, 1999 | Cornell University, National Cancer Institute (NCI) |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 6 | 4 | 1 | 1999 |
| University of Texas at Houston | Academic/Hospital | 2 | 0 | 1 | 2000 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2000 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 1999 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2000 |
| Temple University | Academic/Hospital | 1 | 0 | 1 | 2001 |
6 organizations
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