Minodronate
Small moleculeexperimental
Clinical trial activity
8 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
5
Phase 4
1
Earliest trial started Aug 1, 2002 (NCT00212667)
Timeline
Indications
Approved for
Mechanism of action
- Farnesyl pyrophosphate synthaseANTAGONIST
Farnesyl pyrophosphate synthase antagonist
- Farnesyl diphosphate synthaseINHIBITOR
Farnesyl diphosphate synthase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=P(O)(O)C(O)(Cc1cnc2ccccn12)P(=O)(O)O- Mol. weight
- 322.15 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL319144 ↗
Also known as
- 1-hydroxy-2-(imidazo(1,2-a)pyridin-3-yl)ethane-1,1-bisphosphonic acid monohydrate
- (1-hydroxy-2-(imidazo(1,2-a)-pyridin-3-yl)ethylidene)bisphosphonic acid monohydrate
- minodronate
- minodronate
- minodronic acid
- minodronic acid
- minodronic acid
- minodronic acid
- minodronic acid
- minodronic acid
- minodronic acid hydrate
- minodronic acid hydrate
- ono-5920
- ono-5920
- ono-5920
- phosphonic acid, (1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-
- recalbon
- yh529
- yh 529
- yh-529
- ym529
- ym529
- ym529
- ym529
- ym 529
- ym-529
- ym-529
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05645289 | Phase 4 | Jan 1, 2023 | Peking University |
| NCT05305183 | Phase 3 | May 31, 2022 | Shandong New Time Pharmaceutical Co., LTD |
| NCT02295436 | Phase 1 | Aug 1, 2014 | Huazhong University of Science and Technology |
| NCT00965978 | Phase 1 | Jul 1, 2009 | Astellas, Ono Pharmaceuticals |
| NCT00794443 | Phase 2/Phase 3 (Phase 3) | Nov 1, 2008 | Astellas, Ono Pharmaceuticals |
| NCT00212628 | Phase 3 | Jun 1, 2004 | Astellas, Ono Pharmaceuticals |
| NCT00212719 | Phase 3 | May 1, 2003 | Ono Pharmaceuticals |
| NCT00212667 | Phase 3 | Aug 1, 2002 | Astellas, Ono Pharmaceuticals |
Showing 8 of 8 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ono Pharmaceuticals | For profit | 5 | 3 | 2 | 2002 |
| Astellas | For profit | 4 | 2 | 2 | 2002 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Shandong New Time Pharmaceutical Co., LTD | Government | 1 | 1 | 1 | 2022 |
5 organizations
Page 1 / 1