bi 754091
mAbexperimental
Clinical trial activity
27 trials · 13 clinical orgs · 0 marketing orgs
Phase 1
22
Phase 2
7
Phase 3
1
Phase 4
0
Earliest trial started Nov 21, 2016 (NCT02952248)
Timeline
Indications
Studied for
- Biliary Tract Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Colonic Neoplasms · Phase 1/Phase 2
- Colorectal Neoplasms · Phase 2
- Esophageal Neoplasms · Phase 2
- Gastrointestinal Neoplasms · Phase 1
- Head and Neck Neoplasms · Phase 1
- Intestinal Neoplasms · Phase 1
- Liver Neoplasms · Phase 1/Phase 2
- Lung Neoplasms · Phase 1/Phase 2
- Melanoma · Phase 1
- Myxosarcoma · Phase 3
- Neoplasm Metastasis · Phase 2
- Neoplasms · Phase 1
- Neuroendocrine Tumors · Phase 1/Phase 2
- Pancreatic Neoplasms · Phase 1
- Rectal Neoplasms · Phase 2
- Sarcoma · Phase 3
- Squamous Cell Carcinoma of Head and Neck · Phase 1
- Triple Negative Breast Neoplasms · Phase 2
Mechanism of action
- 80S RibosomeINHIBITOR
80S Ribosome inhibitor
- 60S ribosomal protein L39 (RPL39) ↗
- 60S ribosomal protein L41 (RPL41) ↗
- 40S ribosomal protein S15 (RPS15) ↗
- 40S ribosomal protein S15a (RPS15A) ↗
- 40S ribosomal protein S16 (RPS16) ↗
- 40S ribosomal protein S17 (RPS17) ↗
- 40S ribosomal protein SA (RPSA) ↗
- 40S ribosomal protein S18 (RPS18) ↗
- 40S ribosomal protein S19 (RPS19) ↗
- 40S ribosomal protein S20 (RPS20) ↗
- 40S ribosomal protein S21 (RPS21) ↗
- 40S ribosomal protein S23 (RPS23) ↗
- 40S ribosomal protein S24 (RPS24) ↗
- 40S ribosomal protein S25 (RPS25) ↗
- 40S ribosomal protein S27 (RPS27) ↗
- 40S ribosomal protein S26 (RPS26) ↗
- Ubiquitin-40S ribosomal protein S27a (RPS27A) ↗
- 40S ribosomal protein S28 (RPS28) ↗
- 40S ribosomal protein S29 (RPS29) ↗
- 40S ribosomal protein S30 (RS30) ↗
- 60S ribosomal protein L21 (RPL21) ↗
- 60S ribosomal protein L22 (RPL22) ↗
- 60S ribosomal protein L23 (RPL23) ↗
- 60S ribosomal protein L23a (RPL23A) ↗
- 60S ribosomal protein L24 (RPL24) ↗
- 40S ribosomal protein S6 (RPS6) ↗
- 60S ribosomal protein L26 (RPL26) ↗
- 60S ribosomal protein L27 (RPL27) ↗
- 60S ribosomal protein L27a (RPL27A) ↗
- 60S ribosomal protein L28 (RPL28) ↗
- 60S ribosomal protein L29 (RPL29) ↗
- 60S ribosomal protein L30 (RPL30) ↗
- 60S ribosomal protein L31 (RPL31) ↗
- 60S ribosomal protein L32 (RPL32) ↗
- 60S ribosomal protein L34 (RPL34) ↗
- 60S ribosomal protein L35 (RPL35) ↗
- 60S ribosomal protein L35a (RPL35A) ↗
- 60S ribosomal protein L36 (RPL36) ↗
- 60S ribosomal protein L36a (RPL36A) ↗
- 60S ribosomal protein L37 (RPL37) ↗
- 40S ribosomal protein S10 (RPS10) ↗
- 40S ribosomal protein S11 (RPS11) ↗
- 40S ribosomal protein S12 (RPS12) ↗
- 40S ribosomal protein S13 (RPS13) ↗
- 40S ribosomal protein S14 (RPS14) ↗
- 60S ribosomal protein L37a (RPL37A) ↗
- 40S ribosomal protein S2 (RPS2) ↗
- 40S ribosomal protein S3 (RPS3) ↗
- 40S ribosomal protein S3a (RPS3A) ↗
- 40S ribosomal protein S4, X isoform (RPS4X) ↗
- 40S ribosomal protein S4, Y isoform 1 (RPS4Y1) ↗
- 40S ribosomal protein S5 (RPS5) ↗
- 40S ribosomal protein S7 (RPS7) ↗
- 40S ribosomal protein S8 (RPS8) ↗
- 40S ribosomal protein S9 (RPS9) ↗
- 60S ribosomal protein L3 (RPL3) ↗
- 60S ribosomal protein L4 (RPL4) ↗
- 60S ribosomal protein L5 (RPL5) ↗
- 60S ribosomal protein L6 (RPL6) ↗
- 60S ribosomal protein L7 (RPL7) ↗
- 60S ribosomal protein L7a (RPL7A) ↗
- 60S ribosomal protein L8 (RPL8) ↗
- 60S ribosomal protein L9 (RPL9; RPL9P7; RPL9P8; RPL9P9) ↗
- 60S ribosomal protein L10 (RPL10) ↗
- 60S ribosomal protein L10a (RPL10A) ↗
- 60S ribosomal protein L11 (RPL11) ↗
- 60S ribosomal protein L12 (RPL12) ↗
- 60S ribosomal protein L13 (RPL13) ↗
- 60S ribosomal protein L13a (RPL13A) ↗
- 60S ribosomal protein L14 (RPL14) ↗
- 60S ribosomal protein L15 (RPL15) ↗
- 60S ribosomal protein L17 (RPL17) ↗
- 60S ribosomal protein L18 (RPL18) ↗
- 60S ribosomal protein L18a (RPL18A) ↗
- 60S ribosomal protein L19 (RPL19) ↗
- 60S ribosomal protein L38 (RPL38) ↗
- 60S acidic ribosomal protein P0 (RPLP0) ↗
- 60S acidic ribosomal protein P1 (RPLP1) ↗
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4802172 ↗
Also known as
- bi 754091
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06370871 | Phase 3 | Jun 27, 2024 | Boehringer Ingelheim |
| NCT06091930 | Phase 1 | Jan 15, 2024 | Boehringer Ingelheim |
| NCT06084689 | Phase 2 | Jan 1, 2024 | Boehringer Ingelheim, Institut Bergonié |
| NCT05879978 | Phase 1/Phase 2 (Phase 2) | May 31, 2023 | Boehringer Ingelheim |
| NCT05846516 | Phase 1 | Mar 13, 2023 | Amal Therapeutics, Boehringer Ingelheim, New York University, University of Texas at Houston |
| NCT05471856 | Phase 1 | Jan 9, 2023 | Boehringer Ingelheim |
| NCT05446129 | Phase 1 | Sep 27, 2022 | Boehringer Ingelheim |
| NCT05327946 | Phase 1 | May 9, 2022 | Boehringer Ingelheim |
| NCT05249426 | Phase 1 | Feb 25, 2022 | Boehringer Ingelheim |
| NCT05155332 | Phase 1 | Jan 5, 2022 | Boehringer Ingelheim |
| NCT05068102 | Phase 1 | Nov 16, 2021 | Boehringer Ingelheim |
| NCT04958239 | Phase 1 | Sep 24, 2021 | Boehringer Ingelheim |
| NCT04839471 | Phase 2 | Aug 6, 2021 | Chang Gung University, China Medical University, Government of Taiwan, Kaohsiung Medical University, National Cheng Kung University, Taipei Veteran General hospital, Taiwan Cooperative Oncology Group |
| NCT04752215 | Phase 1 | May 12, 2021 | Boehringer Ingelheim |
| NCT04653142 | Phase 1 | Dec 14, 2020 | Boehringer Ingelheim |
| NCT04499352 | Phase 2 | Sep 14, 2020 | Boehringer Ingelheim |
| NCT04147234 | Phase 1 | Dec 9, 2019 | Boehringer Ingelheim |
| NCT04138823 | Phase 1 | Nov 11, 2019 | Boehringer Ingelheim |
| NCT04046445 | Phase 1/Phase 2 (Phase 2) | Jul 22, 2019 | Amal Therapeutics, Boehringer Ingelheim, University of Texas at Houston |
| NCT03972150 | Phase 1 | Jun 12, 2019 | Boehringer Ingelheim |
Showing 20 of 27 trials
Page 1 / 2
Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Boehringer Ingelheim | For profit | 26 | 22 | 3 | 2016 |
| Amal Therapeutics | For profit | 2 | 2 | 2 | 2019 |
| University of Texas at Houston | Academic/Hospital | 2 | 0 | 2 | 2019 |
| Chang Gung University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| China Medical University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Government of Taiwan | Government | 1 | 1 | 1 | 2021 |
| Institut Bergonié | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Kaohsiung Medical University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| National Cheng Kung University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| New York University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| OSE Immunotherapeutics | For profit | 1 | 1 | 1 | 2019 |
| Taipei Veteran General hospital | Government | 1 | 0 | 1 | 2021 |
| Taiwan Cooperative Oncology Group | Academic/Hospital | 1 | 0 | 1 | 2021 |
13 organizations
Page 1 / 1