ak105
mAbexperimental
Clinical trial activity
22 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
19
Phase 3
4
Phase 4
0
Earliest trial started Dec 22, 2017 (NCT03352531)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 3
- Carcinoma, Non-Small-Cell Lung · Phase 3
- Colorectal Neoplasms · Phase 2
- Esophageal Neoplasms · Phase 3
- Glioblastoma · Phase 2
- Hodgkin Disease · Phase 2
- Intestinal Neoplasms · Phase 2
- Lung Neoplasms · Phase 3
- Nasopharyngeal Carcinoma · Phase 2
- Neoplasms · Phase 2
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Stomach Neoplasms · Phase 2
Mechanism of action
- Programmed cell death protein 1ANTAGONIST
PD1
- 80S RibosomeINHIBITOR
80S Ribosome inhibitor
- 60S ribosomal protein L39 (RPL39) ↗
- 60S ribosomal protein L41 (RPL41) ↗
- 40S ribosomal protein S15 (RPS15) ↗
- 40S ribosomal protein S15a (RPS15A) ↗
- 40S ribosomal protein S16 (RPS16) ↗
- 40S ribosomal protein S17 (RPS17) ↗
- 40S ribosomal protein SA (RPSA) ↗
- 40S ribosomal protein S18 (RPS18) ↗
- 40S ribosomal protein S19 (RPS19) ↗
- 40S ribosomal protein S20 (RPS20) ↗
- 40S ribosomal protein S21 (RPS21) ↗
- 40S ribosomal protein S23 (RPS23) ↗
- 40S ribosomal protein S24 (RPS24) ↗
- 40S ribosomal protein S25 (RPS25) ↗
- 40S ribosomal protein S27 (RPS27) ↗
- 40S ribosomal protein S26 (RPS26) ↗
- Ubiquitin-40S ribosomal protein S27a (RPS27A) ↗
- 40S ribosomal protein S28 (RPS28) ↗
- 40S ribosomal protein S29 (RPS29) ↗
- 40S ribosomal protein S30 (RS30) ↗
- 60S ribosomal protein L21 (RPL21) ↗
- 60S ribosomal protein L22 (RPL22) ↗
- 60S ribosomal protein L23 (RPL23) ↗
- 60S ribosomal protein L23a (RPL23A) ↗
- 60S ribosomal protein L24 (RPL24) ↗
- 40S ribosomal protein S6 (RPS6) ↗
- 60S ribosomal protein L26 (RPL26) ↗
- 60S ribosomal protein L27 (RPL27) ↗
- 60S ribosomal protein L27a (RPL27A) ↗
- 60S ribosomal protein L28 (RPL28) ↗
- 60S ribosomal protein L29 (RPL29) ↗
- 60S ribosomal protein L30 (RPL30) ↗
- 60S ribosomal protein L31 (RPL31) ↗
- 60S ribosomal protein L32 (RPL32) ↗
- 60S ribosomal protein L34 (RPL34) ↗
- 60S ribosomal protein L35 (RPL35) ↗
- 60S ribosomal protein L35a (RPL35A) ↗
- 60S ribosomal protein L36 (RPL36) ↗
- 60S ribosomal protein L36a (RPL36A) ↗
- 60S ribosomal protein L37 (RPL37) ↗
- 40S ribosomal protein S10 (RPS10) ↗
- 40S ribosomal protein S11 (RPS11) ↗
- 40S ribosomal protein S12 (RPS12) ↗
- 40S ribosomal protein S13 (RPS13) ↗
- 40S ribosomal protein S14 (RPS14) ↗
- 60S ribosomal protein L37a (RPL37A) ↗
- 40S ribosomal protein S2 (RPS2) ↗
- 40S ribosomal protein S3 (RPS3) ↗
- 40S ribosomal protein S3a (RPS3A) ↗
- 40S ribosomal protein S4, X isoform (RPS4X) ↗
- 40S ribosomal protein S4, Y isoform 1 (RPS4Y1) ↗
- 40S ribosomal protein S5 (RPS5) ↗
- 40S ribosomal protein S7 (RPS7) ↗
- 40S ribosomal protein S8 (RPS8) ↗
- 40S ribosomal protein S9 (RPS9) ↗
- 60S ribosomal protein L3 (RPL3) ↗
- 60S ribosomal protein L4 (RPL4) ↗
- 60S ribosomal protein L5 (RPL5) ↗
- 60S ribosomal protein L6 (RPL6) ↗
- 60S ribosomal protein L7 (RPL7) ↗
- 60S ribosomal protein L7a (RPL7A) ↗
- 60S ribosomal protein L8 (RPL8) ↗
- 60S ribosomal protein L9 (RPL9; RPL9P7; RPL9P8; RPL9P9) ↗
- 60S ribosomal protein L10 (RPL10) ↗
- 60S ribosomal protein L10a (RPL10A) ↗
- 60S ribosomal protein L11 (RPL11) ↗
- 60S ribosomal protein L12 (RPL12) ↗
- 60S ribosomal protein L13 (RPL13) ↗
- 60S ribosomal protein L13a (RPL13A) ↗
- 60S ribosomal protein L14 (RPL14) ↗
- 60S ribosomal protein L15 (RPL15) ↗
- 60S ribosomal protein L17 (RPL17) ↗
- 60S ribosomal protein L18 (RPL18) ↗
- 60S ribosomal protein L18a (RPL18A) ↗
- 60S ribosomal protein L19 (RPL19) ↗
- 60S ribosomal protein L38 (RPL38) ↗
- 60S acidic ribosomal protein P0 (RPLP0) ↗
- 60S acidic ribosomal protein P1 (RPLP1) ↗
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05718778 | N/A | Mar 20, 2023 | Henan Medical University |
| NCT05563480 | Phase 2 | Oct 27, 2022 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT05683704 | Phase 2 | Sep 1, 2022 | Tianjin Medical University |
| NCT05244993 | Phase 2 | Jul 31, 2022 | Anshan Tumor Hospital, Dalian Medical University, Fukuang General Hospital of Liaoning health industry group, Huludao central hospital |
| NCT05333276 | Phase 1 | May 31, 2022 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT05313906 | Phase 2 | May 7, 2022 | Henan Medical University, Henan Provincal People's Hospital, Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT05068206 | Phase 2 | Oct 8, 2021 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT05033587 | Phase 2 | Sep 30, 2021 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd, Nanjing University |
| NCT04736810 | Phase 2 | Feb 28, 2021 | Akeso Pharmaceuticals, Inc., Chinese Academy of Medical Sciences |
| NCT04736823 | Phase 2 | Feb 1, 2021 | Akeso Pharmaceuticals, Inc., Sun Yat-Sen University |
| NCT04385550 | Phase 3 | May 20, 2020 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT04344158 | Phase 3 | May 1, 2020 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT04291248 | Phase 2 | Mar 31, 2020 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT04207463 | Phase 2 | Jan 1, 2020 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT04203719 | Phase 2 | Jan 1, 2020 | Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd |
| NCT04172506 | Phase 1/Phase 2 (Phase 2) | Aug 28, 2019 | Akeso Pharmaceuticals, Inc., Zhejiang University |
| NCT03866967 | Phase 2 | Mar 1, 2019 | Akeso Pharmaceuticals, Inc., Fudan University |
| NCT03866993 | Phase 3 | Dec 20, 2018 | Akeso Pharmaceuticals, Inc., Jiao Tong University, People's Liberation Army of China |
| NCT03866980 | Phase 3 | Nov 27, 2018 | Akeso Pharmaceuticals, Inc., Jiao Tong University, People's Liberation Army of China |
| NCT04172571 | Phase 2 | Nov 22, 2018 | Akeso Pharmaceuticals, Inc., People's Liberation Army of China |
Showing 20 of 22 trials
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Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd | For profit | 10 | 8 | 3 | 2020 |
| Akeso Pharmaceuticals, Inc. | For profit | 9 | 9 | 3 | 2017 |
| People's Liberation Army of China | Government | 3 | 0 | 2 | 2018 |
| Henan Medical University | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Jiao Tong University | Academic/Hospital | 2 | 0 | 1 | 2018 |
| Anshan Tumor Hospital | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Dalian Medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Fudan University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Fukuang General Hospital of Liaoning health industry group | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Henan Provincal People's Hospital | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Huludao central hospital | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Nanjing University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Tianjin Medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Zhejiang University | Academic/Hospital | 1 | 0 | 1 | 2019 |
16 organizations
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