orismilast
Small moleculeexperimental
Clinical trial activity
13 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
9
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2011 (NCT01310049)
Timeline
Indications
Mechanism of action
- Phosphodiesterase 4AINHIBITOR
PDE4A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c2c1OC1(CCS(=O)(=O)CC1)O2- Mol. weight
- 510.3 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3654384 ↗
Also known as
- leo32731
- leo 32731
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05490316 | Phase 1 | Sep 1, 2022 | Innovent Biologics (Suzhou) Co. Ltd. |
| NCT05469464 | Phase 2 | Jul 11, 2022 | Union Therapeutics |
| NCT05190419 | Phase 2 | Dec 30, 2021 | Union Therapeutics |
| NCT04982432 | Phase 2 | Oct 1, 2021 | Union Therapeutics, University of Copenhagen |
| NCT03812198 | Phase 1 | Jan 22, 2019 | Leo Pharma |
| NCT03231124 | Phase 1 | Jul 25, 2017 | Leo Pharma, Richmond Pharmacology |
| NCT03126578 | Phase 1 | May 31, 2017 | Leo Pharma, Nuvisan Pharma Services |
| NCT02888236 | Phase 2 | Sep 1, 2016 | Humboldt University, Leo Pharma |
| NCT02753218 | Phase 1 | Apr 1, 2016 | Leo Pharma |
| NCT02514694 | Phase 1 | Jul 1, 2015 | Leo Pharma |
| NCT02496546 | Phase 1 | Jul 1, 2015 | Leo Pharma |
| NCT02126371 | Phase 1 | May 1, 2014 | Covance, Leo Pharma |
| NCT01310049 | Phase 1 | Mar 1, 2011 | Covance, Leo Pharma |
Showing 13 of 13 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Leo Pharma | For profit | 9 | 9 | 2 | 2011 |
| Union Therapeutics | For profit | 3 | 2 | 1 | 2021 |
| Covance | For profit | 2 | 0 | 1 | 2011 |
| Humboldt University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Innovent Biologics (Suzhou) Co. Ltd. | For profit | 1 | 1 | 1 | 2022 |
| Nuvisan Pharma Services | For profit | 1 | 0 | 1 | 2017 |
| Richmond Pharmacology | For profit | 1 | 0 | 1 | 2017 |
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2021 |
8 organizations
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