faldaprevir

Small moleculeexperimental

Faldaprevir was an experimental drug for the treatment of hepatitis C (HCV). It was being developed by Boehringer-Ingelheim and reached Phase III clinical trials in 2011. Boehringer announced in 2014 that it would not pursue approval of the drug any more because of better HCV treatments having become available. — Wikipedia

Clinical trial activity

49 trials · 5 clinical orgs · 0 marketing orgs

Phase 1
30
Phase 2
19
Phase 3
10
Phase 4
0

Earliest trial started Oct 1, 2004 (NCT02182271)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(=O)C(C)C)n3)nc3c(Br)c(OC)ccc23)CN1C(=O)[C@@H](NC(=O)OC1CCCC1)C(C)(C)C)C(=O)O
Mol. weight
869.84 g/mol
Lipinski Ro5
3 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • bi201335
  • bi201335
  • bi201335
  • bi 201335
  • bi 201335
  • bi 201335
  • bi 201335
  • bi-201335
  • bi-201335
  • bi-201335
  • faldaprevir
  • faldaprevir
  • faldaprevir
  • faldaprevir
  • faldaprevir
  • faldeprevir
  • n-((cyclopentyloxy)carbonyl)-3-methylvalyl-4-((8-bromo-7-methoxy-2-(2-((2-methylpropanoyl)amino)-1,3-thiazol-4-yl)quinolin-4-yl)oxy)-n-(1-carboxy-2-ethenylcyclopropyl)prolinamide

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02716428Phase 2May 1, 2016Auckland Clinical Studies, Southern California Research Center, Trek Therapeutics, PBC
NCT02593162Phase 2Oct 1, 2015Southern California Research Center, Trek Therapeutics, PBC
NCT02114671Phase 1Apr 1, 2014Boehringer Ingelheim
NCT02016625Phase 1Dec 1, 2013Boehringer Ingelheim
NCT01941615Phase 1Nov 1, 2013Boehringer Ingelheim
NCT01957657Phase 1Oct 1, 2013Boehringer Ingelheim
NCT01965431Phase 1Oct 1, 2013Boehringer Ingelheim
NCT01859962Phase 2May 1, 2013Boehringer Ingelheim, Presidio Pharmaceuticals
NCT01858961Phase 3May 1, 2013Boehringer Ingelheim
NCT01830127Phase 2Apr 1, 2013Boehringer Ingelheim
NCT01821937Phase 1Mar 1, 2013Boehringer Ingelheim
NCT01795937Phase 1Feb 1, 2013Boehringer Ingelheim
NCT01785160Phase 1Feb 1, 2013Boehringer Ingelheim
NCT01764945Phase 1Jan 1, 2013Boehringer Ingelheim
NCT01732796Phase 3Dec 1, 2012Boehringer Ingelheim
NCT01728324Phase 3Nov 1, 2012Boehringer Ingelheim
NCT01737996Phase 1Nov 1, 2012Boehringer Ingelheim
NCT01704846Phase 1Oct 1, 2012Boehringer Ingelheim
NCT01694706Phase 1Sep 1, 2012Boehringer Ingelheim
NCT01608737Phase 3Sep 1, 2012Boehringer Ingelheim
Showing 20 of 49 trials
Page 1 / 3

Organizations

Research & Development (5)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Boehringer IngelheimFor profit474632004
Southern California Research CenterFor profit2012015
Trek Therapeutics, PBCFor profit2212015
Auckland Clinical StudiesFor profit1012016
Presidio PharmaceuticalsFor profit1112013
5 organizations
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