anagliptin
Small moleculeexperimental
Anagliptin is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. It is approved for use in Japan. It belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins". — Wikipedia
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
2
Phase 4
3
Earliest trial started Feb 1, 2009 (NCT00888719)
Timeline
Indications
Approved for
Mechanism of action
Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) antagonist
- Dipeptidyl peptidase IVINHIBITOR
Dipeptidyl peptidase IV inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)cn2n1.Cl- Mol. weight
- 419.92 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAnagliptin ↗
- ChEMBLCHEMBL1929396 ↗
- ChEMBLCHEMBL1929387 ↗
Also known as
- anagliptin
- anagliptin
- anagliptin
- anagliptin
- anagliptin
- anagliptin
- anagliptin hcl
- anagliptin hcl
- anagliptin hcl
- anagliptin hcl
- anagliptin hydrochloride
- anagliptin hydrochloride
- beskoa
- n-(2-((2-((2s)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)-2-methyl pyrazolo(1,5-a)pyrimidine-6-carboxamide hydrochloride
- suiny
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04810507 | Phase 4 | Nov 9, 2018 | JW Pharmaceutical |
| NCT03014479 | Phase 4 | Jan 12, 2017 | Takeda |
| NCT02330406 | Phase 4 | Jan 1, 2015 | Institute for Clinical Effectiveness, Japan, University of the Ryukyus |
| NCT01529528 | Phase 3 | May 1, 2011 | JW Pharmaceutical, Kangbuk Samsung Hospital |
| NCT01529541 | Phase 3 | May 1, 2011 | JW Pharmaceutical |
| NCT00888719 | Phase 2 | Feb 1, 2009 | Catholic University of Korea, JW Pharmaceutical |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| JW Pharmaceutical | For profit | 4 | 4 | 3 | 2009 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Institute for Clinical Effectiveness, Japan | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Kangbuk Samsung Hospital | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Takeda | For profit | 1 | 1 | 1 | 2017 |
| University of the Ryukyus | Academic/Hospital | 1 | 0 | 1 | 2015 |
6 organizations
Page 1 / 1