rp-3500
Small moleculeexperimental
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Jul 22, 2020 (NCT04497116)
Timeline
2020s
- Jan 1, 2020
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Carcinoma, Squamous Cell · Phase 1
- Head and Neck Neoplasms · Phase 1
- Hypopharyngeal Neoplasms · Phase 1
- Laryngeal Neoplasms · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1/Phase 2
- Mouth Neoplasms · Phase 1
- Neoplasms · Phase 1/Phase 2
- Oropharyngeal Neoplasms · Phase 1
- Squamous Cell Carcinoma of Head and Neck · Phase 1
Mechanism of action
- ATR/ATRIPINHIBITOR
ATR/ATRIP inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H]1COCCN1c1cc([C@]2(O)C[C@H]3CC[C@@H](C2)O3)c2cnn(-c3cc[nH]n3)c2n1- Mol. weight
- 410.48 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5095260 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07156227 | Phase 1 | Dec 26, 2025 | National Cancer Institute (NCI), University of Pittsburgh |
| NCT05566574 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2022 | Memorial Sloan-Kettering Cancer Center, Repare Therapeutics |
| NCT05405309 | Phase 1/Phase 2 (Phase 2) | Sep 23, 2022 | Repare Therapeutics, University of Utah |
| NCT04972110 | Phase 1/Phase 2 (Phase 2) | Jul 21, 2021 | Repare Therapeutics |
| NCT04497116 | Phase 1/Phase 2 (Phase 2) | Jul 22, 2020 | Repare Therapeutics, University of Texas at Houston |
Showing 5 of 5 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Repare Therapeutics | For profit | 4 | 2 | 1 | 2020 |
| Memorial Sloan-Kettering Cancer Center | Academic/Hospital | 1 | 1 | 1 | 2022 |
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2025 |
| University of Pittsburgh | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University of Utah | Academic/Hospital | 1 | 1 | 1 | 2022 |
6 organizations
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