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benserazide

Small moleculeexperimental

Clinical trial activity

24 trials · 19 clinical orgs · 0 marketing orgs

Phase 1
11
Phase 2
8
Phase 3
3
Phase 4
4

Earliest trial started Apr 1, 2001 (NCT02763852)

Timeline

2000s

  1. Jan 1, 2001

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • DOPA decarboxylaseINHIBITOR

    DDC inhibitor

    Benserazide has little therapeutic effect on its own, and its effect occurs synergically in combination with levodopa. Levodopa is a precursor to the neurotransmitter dopamine which is administered to increase its levels in the central nervous system. However, most levodopa is decarboxylated to dopamine before it reaches the brain, and since dopamine is unable to cross the blood¿brain barrier, this translates to little therapeutic gain with strong peripheral side effects. Benserazide, a DOPA decarboxylase inhibitor, prevents the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. Benserazide cannot cross the blood¿brain barrier.

Chemistry & pharmacology

Loading structure…

SMILES

NC(CO)C(=O)NNCc1ccc(O)c(O)c1O
Mol. weight
257.25 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • benserazide
  • benserazide
  • benserazide
  • benserazide
  • benserazide
  • benserazide
  • benserazide hcl
  • benserazide hcl
  • benserazide hcl
  • benserazide hydrochloride
  • benserazide hydrochloride
  • benserazide hydrochloride
  • benserazide hydrochloride
  • benserazide hydrochloride
  • ro-44602
  • ro-44602
  • serazide

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06034158N/ASep 18, 2023Zhejiang University
NCT04990284Phase 4Nov 30, 2021Bial
NCT04821687Phase 4Jun 17, 2021SK Chemicals
NCT04432623Phase 1/Phase 2 (Phase 2)Aug 30, 2020National Heart, Lung, and Blood Institute (NHLBI), Phoenicia BioScience, University of California, San Francisco, University of Toronto
NCT04968613Phase 4Jan 1, 2018Chinese Academy of Medical Sciences, Peking University
NCT02680977Phase 2Feb 1, 2016ASST Gaetano Pini-CTO, Fondazione Grigioni per il Morbo di Parkinson
NCT03333369Early Phase 1 (Phase 1)May 15, 2014Swiss Federal Institute of Technology, University of Zurich
NCT01568073Phase 3Mar 1, 2011Bial
NCT01227655Phase 3Mar 1, 2011Bial
NCT01568047Phase 2Feb 1, 2010Bial
NCT02169414Phase 1Feb 1, 2010Bial
NCT01327261Phase 4Aug 1, 2009Laboratorios Phoenix, University of Buenos Aires
NCT01568034Phase 2Apr 1, 2009Bial, University of Lisbon
NCT01533116Phase 1Mar 1, 2009Algorithme Pharma Inc, Bial
NCT02169466Phase 1Jan 1, 2009Bial
NCT02169895Phase 1Sep 1, 2008Bial
NCT00941265N/AFeb 1, 2007University of Geneva
NCT03103399Phase 2Sep 26, 2006Bial
NCT03097211Phase 1Jul 17, 2006Bial
NCT03094156Phase 1Apr 26, 2006Bial
Showing 20 of 24 trials
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Organizations

Research & Development (19)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
BialFor profit151542001
Algorithme Pharma IncFor profit1012009
ASST Gaetano Pini-CTOAcademic/Hospital1112016
Boehringer IngelheimFor profit1112003
Chinese Academy of Medical SciencesAcademic/Hospital1012018
Fondazione Grigioni per il Morbo di ParkinsonAcademic/Hospital1012016
Laboratorios PhoenixFor profit1012009
National Heart, Lung, and Blood Institute (NHLBI)Government1012020
Peking UniversityAcademic/Hospital1112018
Phoenicia BioScienceFor profit1112020
SK ChemicalsFor profit1112021
Swiss Federal Institute of TechnologyAcademic/Hospital1012014
University of Buenos AiresAcademic/Hospital1112009
University of California, San FranciscoAcademic/Hospital1012020
University of GenevaAcademic/Hospital1112007
University of LisbonAcademic/Hospital1012009
University of TorontoAcademic/Hospital1012020
University of ZurichAcademic/Hospital1112014
Zhejiang UniversityAcademic/Hospital1112023
19 organizations
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