spermidine
Small moleculeexperimental
A polyamine is an organic compound having two or more amino groups. Alkyl polyamines occur naturally, but some are synthetic. Alkylpolyamines are colorless, hygroscopic, and water soluble. Near neutral pH, they exist as the ammonium derivatives. Most aromatic polyamines are crystalline solids at room temperature. — Wikipedia
Clinical trial activity
12 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
1
Phase 4
1
Earliest trial started Jan 1, 2013 (NCT02083003)
Timeline
Indications
Approved for
Studied for
- Cardiovascular Diseases · Phase 2
- Cognition Disorders · Phase 2
- Cognitive Dysfunction · Phase 2
- Diabetes Mellitus, Type 2 · Phase 2
- Feeding Behavior · Phase 2
- General Surgery · Phase 4
- Heart Diseases · Phase 2
- Heart Failure, Diastolic · Phase 2
- Hypertension · Phase 3
- Inflammation · Phase 2
- Metabolic Syndrome · Phase 2
- Myocardial Infarction · Phase 2
- Myocardial Ischemia · Phase 2
- Obesity · Phase 2
- Quality of Life · Phase 2
- Smokers · Phase 1
- Vascular Diseases · Phase 2
- Xerostomia · Phase 1/Phase 2
Mechanism of action
- Histone acetyltransferase PCAFINHIBITOR
KAT2B inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
NCCCCNCCCN- Mol. weight
- 145.25 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPolyamine ↗
- ChEMBLCHEMBL19612 ↗
- WikipediaSpermidine ↗
Also known as
- polyamine
- polyamine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07202403 | N/A | Sep 30, 2025 | Atria Research and Global Health Institute (ARGHI) |
| NCT07058974 | Phase 1 | Aug 25, 2025 | Icahn School of Medicine at Mount Sinai |
| NCT07035626 | Phase 1/Phase 2 (Phase 2) | Jun 25, 2025 | Sichuan University |
| NCT06186102 | Phase 2 | Jan 31, 2024 | Aarhus University, Danish Cardiovascular Research Academy, Danish Diabetes Academy, DoNotAge.org |
| NCT06017219 | N/A | May 5, 2023 | — |
| NCT05459961 | N/A | Aug 31, 2022 | Biofortis |
| NCT05421546 | N/A | Aug 1, 2022 | University of Oxford |
| NCT05017428 | N/A | Apr 8, 2021 | University of California, Davis |
| NCT04405388 | Phase 3 | Feb 25, 2020 | Institut National de la Santé Et de la Recherche Médicale, France, Medical University of Graz, University of Tuebingen, University of Zurich |
| NCT03094546 | Phase 2 | Jan 1, 2017 | Humboldt University |
| NCT02755246 | Phase 2 | Apr 1, 2016 | Humboldt University |
| NCT02083003 | Phase 4 | Jan 1, 2013 | University of Versailles |
Showing 12 of 12 trials
Page 1 / 1
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Humboldt University | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Atria Research and Global Health Institute (ARGHI) | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Biofortis | For profit | 1 | 0 | 1 | 2022 |
| Danish Cardiovascular Research Academy | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Danish Diabetes Academy | Academic/Hospital | 1 | 0 | 1 | 2024 |
| DoNotAge.org | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Institut National de la Santé Et de la Recherche Médicale, France | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Medical University of Graz | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of California, Davis | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Oxford | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Tuebingen | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University of Versailles | Academic/Hospital | 1 | 1 | 1 | 2013 |
| University of Zurich | Academic/Hospital | 1 | 0 | 1 | 2020 |
16 organizations
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