levobetaxolol
Trade name: betaxon
Approved
Feb 23, 2000
BETAXON™ is a trade name for levobetaxolol hydrochloride ophthalmic suspension 0.5%, which is indicated for lowering intraocular pressure in patients with chronic open-angle glaucoma or ocular hypertension. The brand name Betaxon is discontinued in USA, but generic versions may be available. Levobetaxolol is a cardioselective (beta-1¬ adrenergic) receptor-blocking agent that does not have significant membrane-stabilizing (local anesthetic) activity and is devoid of intrinsic sympathomimetic action. Animal studies suggest levobetaxolol (S-isomer) is the more active enantiomer of betaxolol (racemate). — NCATS
Clinical trial activity
2 trials · 3 clinical orgs · 2 marketing orgs
Earliest trial started Jan 1, 2003 (NCT00061516)
Timeline
Indications
Mechanism of action
- Beta-1 adrenergic receptorANTAGONIST
ADRB1 antagonist
Approval history
- approvedPriority reviewFeb 23, 2000
Chemistry & pharmacology
SMILES
CC(C)NC[C@H](O)COc1ccc(CCOCC2CC2)cc1- Mol. weight
- 307.43 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL1201274 ↗
- WikipediaLevobetaxolol ↗
- NCATS75O9XHA4TU ↗
- ChEMBLCHEMBL1200837 ↗
Also known as
- al-1577a
- al-1577a
- (-)-betaxolol
- betaxon
- betaxon
- betaxon
- betaxon
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol
- levobetaxolol hcl
- levobetaxolol hcl
- levobetaxolol hcl
- levobetaxolol hydrochloride
- levobetaxolol hydrochloride
- levobetaxolol hydrochloride
- levobetaxolol hydrochloride
- (s)-betaxolol
- (s)-betaxolol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02617459 | Phase 3 | Nov 1, 2015 | Lee's Pharmaceutical, Xiamen University |
| NCT00061516 | Phase 3 | Jan 1, 2003 | Alcon |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Alcon | For profit | 1 | 1 | 1 | 2003 |
| Lee's Pharmaceutical | For profit | 1 | 1 | 1 | 2015 |
| Xiamen University | Academic/Hospital | 1 | 0 | 1 | 2015 |