candida urate oxidase
Recombinant proteinexperimental
The enzyme urate oxidase (UO), uricase or factor-independent urate hydroxylase, absent in humans, catalyzes the oxidation of uric acid to 5-hydroxyisourate:Uric acid + O2 + H2O → 5-hydroxyisourate + H2O2 5-hydroxyisourate + H2O → 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline → allantoin + CO2 — Wikipedia
Clinical trial activity
4 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Feb 28, 2018 (NCT03436732)
Timeline
Indications
Mechanism of action
- Uric acidDEGRADER
Uric acid degrader
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaUrate oxidase ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05226013 | Phase 1 | Dec 8, 2021 | Qingdao University |
| NCT04047394 | Phase 1 | Aug 30, 2019 | Sunshine Lake Pharma Co., Ltd. |
| NCT03905512 | Phase 2 | Mar 28, 2019 | Selecta Biosciences, Inc. |
| NCT03436732 | Phase 1 | Feb 28, 2018 | National Cancer Institute (NCI) |
Showing 4 of 4 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 1 | 1 | 1 | 2018 |
| Qingdao University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Selecta Biosciences, Inc. | For profit | 1 | 1 | 1 | 2019 |
| Sunshine Lake Pharma Co., Ltd. | For profit | 1 | 1 | 1 | 2019 |
4 organizations
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