Aspacytarabine
Small moleculeexperimental
Clinical trial activity
4 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Aug 14, 2018 (NCT03435848)
Timeline
Indications
Mechanism of action
- RNADISRUPTING AGENT
RNA disrupting agent
- DNADISRUPTING AGENT
DNA disrupting agent
- DNA polymerase nuINHIBITOR
POLN inhibitor
- DNA polymerase (alpha/delta/epsilon)INHIBITOR
DNA polymerase (alpha/delta/epsilon) inhibitor
- DNA polymerase alpha catalytic subunit (POLA1) ↗
- DNA polymerase delta subunit 4 (POLD4) ↗
- DNA polymerase delta subunit 3 (POLD3) ↗
- DNA polymerase delta catalytic subunit (POLD1) ↗
- DNA polymerase delta subunit 2 (POLD2) ↗
- DNA polymerase epsilon catalytic subunit A (POLE) ↗
- DNA polymerase alpha subunit B (POLA2) ↗
- DNA primase small subunit (PRIM1) ↗
- DNA primase large subunit (PRIM2) ↗
- DNA polymerase epsilon subunit 2 (POLE2) ↗
- DNA polymerase epsilon subunit 3 (POLE3) ↗
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CC(=O)Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1)C(=O)O- Mol. weight
- 358.31 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL4297599 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05503355 | Phase 1/Phase 2 (Phase 2) | Aug 17, 2022 | BioSight Ltd. |
| NCT04749355 | Phase 2 | Aug 14, 2021 | BioSight Ltd. |
| NCT04827719 | Phase 2 | May 1, 2021 | Groupe Francophone des Myelodysplasies, Institut Paoli-Calmettes, University of Paris |
| NCT03435848 | Phase 2 | Aug 14, 2018 | BioSight Ltd. |
Showing 4 of 4 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioSight Ltd. | For profit | 3 | 3 | 1 | 2018 |
| Groupe Francophone des Myelodysplasies | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Institut Paoli-Calmettes | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Paris | Academic/Hospital | 1 | 0 | 1 | 2021 |
4 organizations
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