2'-fucosyllactose
Small moleculeexperimental
2′-Fucosyllactose (2′-FL) is a fucosylated neutral trisaccharide composed of L-fucose, D-galactose, and D-glucose units. It is the most prevalent human milk oligosaccharide (HMO) naturally present in human breast milk, making up about 30% of all of HMOs. It was first discovered in the 1950s in human milk. The oligosaccharide's primary isolation technique has been in use since 1972. — Wikipedia
Clinical trial activity
6 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jul 4, 2018 (NCT04718662)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Toll-like receptor 4INHIBITOR
TLR4 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H]1O[C@@H](O[C@H]2[C@H](O[C@@H]([C@H](O)[C@@H](O)C=O)[C@H](O)CO)O[C@H](CO)[C@H](O)[C@@H]2O)[C@@H](O)[C@H](O)[C@@H]1O- Mol. weight
- 488.44 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- Wikipedia2'-Fucosyllactose ↗
- ChEMBLCHEMBL4297252 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06050811 | N/A | Nov 30, 2023 | Berkshire Healthcare NHS Foundation Trust, University of Reading |
| NCT06547801 | N/A | May 4, 2023 | Advanced Protein Technologies Corporation |
| NCT05521061 | N/A | May 28, 2022 | Acibadem University, Ege University, Eskisehir Osmangazi University |
| NCT04263597 | Phase 1/Phase 2 (Phase 2) | Mar 31, 2020 | University of Cincinnati |
| NCT03847467 | Phase 1/Phase 2 (Phase 2) | Mar 31, 2019 | Broad Institute, University of Cincinnati, University of Connecticut |
| NCT04718662 | N/A | Jul 4, 2018 | Ohio State University |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Cincinnati | Academic/Hospital | 2 | 2 | 1 | 2019 |
| Acibadem University | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Advanced Protein Technologies Corporation | For profit | 1 | 1 | 1 | 2023 |
| Berkshire Healthcare NHS Foundation Trust | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Broad Institute | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Ege University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Eskisehir Osmangazi University | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Ohio State University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Connecticut | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Reading | Academic/Hospital | 1 | 0 | 1 | 2023 |
10 organizations
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