bacillus cereus
Bacillus cereus is a Gram-positive rod-shaped bacterium commonly found in soil, food, and marine sponges. The specific name, cereus, meaning "waxy" in Latin, refers to the appearance of colonies grown on blood agar. Some strains are harmful to humans and cause foodborne illness due to their spore-forming nature, while other strains can be beneficial as probiotics for animals, and even exhibit mutualism with certain plants. B. cereus bacteria may be aerobes or facultative anaerobes, and like other members of the genus Bacillus, can produce protective endospores. They have a wide range of virulence factors, including phospholipase C, cereulide, sphingomyelinase, metalloproteases, and cytotoxin K, many of which are regulated via quorum sensing. B. cereus strains exhibit flagellar motility. — Wikipedia
Clinical trial activity
2 trials · 7 clinical orgs · 0 marketing orgs
Earliest trial started Apr 15, 2018 (NCT03486587)
Timeline
2010s
- Jan 1, 2018
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBacillus cereus ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04982380 | Phase 4 | Jul 31, 2021 | Chengde Medical University, Chinese Academy of Medical Sciences, Hangzhou Grand Biologic Pharmaceutical, Inc., Harbin Medical University, Inner Mongolia Medical University, Zhengzhou University |
| NCT03486587 | Phase 2 | Apr 15, 2018 | Sun Yat-Sen University |
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Chengde Medical University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Hangzhou Grand Biologic Pharmaceutical, Inc. | Government | 1 | 0 | 1 | 2021 |
| Harbin Medical University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Inner Mongolia Medical University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Zhengzhou University | Academic/Hospital | 1 | 0 | 1 | 2021 |