s-adenosyl methionine
S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952. — Wikipedia
Clinical trial activity
37 trials · 50 clinical orgs · 0 marketing orgs
Earliest trial started Jul 1, 2003 (NCT00070941)
Timeline
Indications
Approved for
Studied for
- Alcohol Withdrawal Delirium · Phase 3
- Carcinoma, Hepatocellular · Phase 1
- Cholestasis · Phase 4
- Depression · Phase 2/Phase 3
- Fibromyalgia · Phase 2
- Healthy Volunteers · Phase 2
- Hepatitis · Phase 3
- Hepatitis, Alcoholic · Phase 4
- Hepatitis B · Phase 4
- Hepatitis C · Phase 2/Phase 3
- Hepatitis C, Chronic · Phase 2
- HIV Infections · Phase 4
- Hot Flashes · Phase 2
- Hyperhomocysteinemia · Phase 1
- Liver Cirrhosis, Biliary · Phase 4
- Liver Diseases, Alcoholic · Phase 3
- Liver Neoplasms · Phase 2
- Major Depressive Disorder · Phase 1
- Non-alcoholic Fatty Liver Disease · Phase 3
- Parkinson Disease · Phase 2/Phase 3
- Tobacco Use Disorder · Phase 2/Phase 3
Mechanism of action
- methionineSupplementation
methionine supplementation
Chemistry & pharmacology
SMILES
C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O- Mol. weight
- 398.45 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaS-Adenosyl methionine ↗
- ChEMBLCHEMBL1088977 ↗
Also known as
- ademethionine
- ademethionine
- ademetionin
- ademetionin
- ademetionin
- ademetionin
- ademetionin
- ademetionine
- ademetionine
- ademetionine
- ademetionine
- ademetionine
- adomet
- adomet
- donamet
- methioninyl adenylate
- moodplus
- msi-195
- s-adenosyl-l-methionine
- s-adenosyl-l-methionine
- s-adenosyl methione
- s-adenosylmethionine
- s-adenosylmethionine
- s-adenosylmethionine
- s-adenosylmethionine
- s-adenosyl methionine
- s-adenosyl methionine
- sam
- sam
- same
- same
- sam-e
- sam-e
- sam-e
- samyr 200
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07068191 | N/A | Jun 19, 2025 | Phenomen Pharma |
| NCT06026865 | N/A | Aug 1, 2023 | Medical University of Warsaw, National Science Centre, Poland |
| NCT05598580 | Phase 4 | Nov 30, 2022 | Zhejiang University |
| NCT05363020 | N/A | Jun 1, 2022 | Dartmouth University |
| NCT04250259 | N/A | Mar 1, 2020 | Indiana University |
| NCT03938662 | N/A | May 9, 2019 | University Clinic Dr Dragisa Misovic-Dedinje |
| NCT03932474 | N/A | Sep 17, 2018 | Hippocrates Research, Nutrilinea srl |
| NCT03178929 | N/A | Jul 1, 2017 | Beijing Insight Science & Technology Co. Ltd. |
| NCT02557360 | Phase 4 | Nov 1, 2015 | Laval University, Pomeranian Medical University |
| NCT02586285 | Phase 1 | Jun 1, 2015 | Eastern Hepatobiliary Surgery Hospital, People's Liberation Army of China |
| NCT02264860 | N/A | Oct 1, 2014 | Emory University, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) |
| NCT02200029 | Phase 3 | Jun 1, 2014 | Abbott, Catalent, ClinIntel |
| NCT02231333 | N/A | Jun 1, 2014 | Institute of Liver and Biliary Sciences, India |
| NCT02024295 | Phase 4 | Dec 1, 2013 | Capital Medical University, Zhejiang Hisun Pharmaceutical Co. Ltd. |
| NCT01998620 | Phase 4 | Nov 1, 2013 | Fudan University, Zhejiang Hisun Pharmaceutical Co. Ltd. |
| NCT01912196 | Phase 2 | Oct 1, 2013 | MSI Methylation Sciences, Inc. |
| NCT01899521 | N/A | May 1, 2013 | Department of Veteran Affairs |
| NCT04623034 | Phase 1 | Apr 17, 2013 | Algorithme Pharma Inc, MSI Methylation Sciences, Inc. |
| NCT01806870 | N/A | Mar 1, 2013 | Emory University, National Heart, Lung, and Blood Institute (NHLBI) |
| NCT01754714 | Phase 3 | Dec 1, 2012 | Abbott, PPD |