keratin
Keratin is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents. Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive keratinization participate in fortification of certain tissues such as in horns of cattle and rhinos, and armadillos' osteoderm. The only other biological matter known to approximate the toughness of keratinized tissue is chitin. Keratin comes in two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids. — Wikipedia
Clinical trial activity
4 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Jan 15, 2020 (NCT04249128)
Timeline
2020s
- Jan 1, 2020
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- Keratin, type II cytoskeletal 1Supplementation
KRT1 supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaKeratin ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06612866 | N/A | Oct 30, 2024 | BCF Life Sciences, Clinic'n'Cell, University Clermont Auvergne |
| NCT06605768 | N/A | Feb 19, 2024 | Nutra Harmony LLC |
| NCT04884347 | N/A | Aug 31, 2020 | Complife Italia Srl, Laboratoires Pharmaceutiques Trenker, Università degli Studi di Pavia |
| NCT04249128 | Phase 3 | Jan 15, 2020 | Noho Health, ProofPilot |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BCF Life Sciences | For profit | 1 | 1 | 1 | 2024 |
| Clinic'n'Cell | For profit | 1 | 0 | 1 | 2024 |
| Complife Italia Srl | For profit | 1 | 0 | 1 | 2020 |
| Laboratoires Pharmaceutiques Trenker | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Noho Health | For profit | 1 | 0 | 1 | 2020 |
| Nutra Harmony LLC | For profit | 1 | 1 | 1 | 2024 |
| ProofPilot | For profit | 1 | 1 | 1 | 2020 |
| Università degli Studi di Pavia | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University Clermont Auvergne | Academic/Hospital | 1 | 0 | 1 | 2024 |