ab154
mAbexperimental
Clinical trial activity
21 trials · 20 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
18
Phase 3
4
Phase 4
0
Earliest trial started Aug 21, 2018 (NCT03628677)
Timeline
Indications
Studied for
- Adenocarcinoma · Phase 3
- Carcinoid Tumor · Phase 2
- Carcinoma, Hepatocellular · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 3
- Carcinoma, Transitional Cell · Phase 2
- Cholangiocarcinoma · Phase 2
- Dyslipidemias · Phase 1
- Esophageal Neoplasms · Phase 2
- Gestational Trophoblastic Disease · Phase 2
- Glioblastoma · Early Phase 1
- Liver Neoplasms · Phase 2
- Lung Neoplasms · Phase 3
- Melanoma · Phase 2
- Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 2
- Peritoneal Neoplasms · Phase 2
- Small Cell Lung Carcinoma · Phase 3
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Stomach Neoplasms · Phase 2
- Thymoma · Phase 2
- Thyroid Carcinoma, Anaplastic · Phase 2
- Triple Negative Breast Neoplasms · Phase 2
Mechanism of action
TIGIT antagonist
T-cell immunoreceptor with Ig and ITIM domains inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4650392 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07283848 | Phase 2 | Feb 1, 2026 | Arcus Biosciences, Inc., Gateway for Cancer Research, Harvard University |
| NCT07134556 | Phase 2 | Dec 8, 2025 | MedSIR, University of Bristol |
| NCT07152873 | Phase 1 | Oct 20, 2025 | Addpharma Inc. |
| NCT06790706 | Phase 2 | Oct 1, 2025 | University of Lyon |
| NCT06727565 | Phase 2 | Dec 31, 2024 | Arcus Biosciences, Inc., Gilead Sciences |
| NCT06250036 | Phase 2 | Apr 1, 2024 | Gilead Sciences, Royal Marsden Hospital NHS Trust |
| NCT06133517 | Phase 2 | Mar 31, 2024 | Apices Soluciones S.L., University of Cantabria |
| NCT05724563 | Phase 2 | Jun 1, 2023 | Arcus Biosciences, Inc., State of Texas, The University of Texas, Dallas |
| NCT05676931 | Phase 2 | Feb 1, 2023 | Arcus Biosciences, Inc., Gilead Sciences |
| NCT05633667 | Phase 2 | Dec 31, 2022 | Gilead Sciences |
| NCT05419479 | Phase 1/Phase 2 (Phase 2) | Nov 30, 2022 | Arcus Biosciences, Inc., Harvard University, Lustgarten Foundation |
| NCT05568095 | Phase 3 | Nov 21, 2022 | Arcus Biosciences, Inc., Gilead Sciences |
| NCT05502237 | Phase 3 | Oct 12, 2022 | Arcus Biosciences, Inc., Gilead Sciences |
| NCT05329766 | Phase 2 | Jun 10, 2022 | Arcus Biosciences, Inc., Gilead Sciences |
| NCT05211895 | Phase 3 | Feb 18, 2022 | Arcus Biosciences, Inc., AstraZeneca, National Cancer Center, Japan, Shandong University |
| NCT05130177 | Phase 2 | Dec 31, 2021 | Arcus Biosciences, Inc., University of Pittsburgh |
| NCT04791839 | Phase 2 | Aug 4, 2021 | Arcus Biosciences, Inc., Washington University in St. Louis |
| NCT04736173 | Phase 3 | Feb 1, 2021 | Arcus Biosciences, Inc. |
| NCT04656535 | Early Phase 1 (Phase 1) | Jan 31, 2021 | Arcus Biosciences, Inc., Yale University |
| NCT04262856 | Phase 2 | Jan 13, 2020 | Arcus Biosciences, Inc. |
Showing 20 of 21 trials
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Organizations
Research & Development (20)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Arcus Biosciences, Inc. | For profit | 15 | 6 | 3 | 2018 |
| Gilead Sciences | For profit | 7 | 3 | 2 | 2022 |
| Harvard University | Academic/Hospital | 2 | 2 | 1 | 2022 |
| Addpharma Inc. | For profit | 1 | 1 | 1 | 2025 |
| Apices Soluciones S.L. | For profit | 1 | 0 | 1 | 2024 |
| AstraZeneca | For profit | 1 | 1 | 1 | 2022 |
| Gateway for Cancer Research | Academic/Hospital | 1 | 0 | 1 | 2026 |
| Lustgarten Foundation | Academic/Hospital | 1 | 0 | 1 | 2022 |
| MedSIR | Academic/Hospital | 1 | 1 | 1 | 2025 |
| National Cancer Center, Japan | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Royal Marsden Hospital NHS Trust | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Shandong University | Academic/Hospital | 1 | 0 | 1 | 2022 |
| State of Texas | Government | 1 | 0 | 1 | 2023 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Bristol | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Cantabria | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Lyon | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Pittsburgh | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Washington University in St. Louis | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Yale University | Academic/Hospital | 1 | 1 | 1 | 2021 |
20 organizations
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